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Popular Reports / endocrinology

This report is written by MaltSci based on the latest literature and research findings

How does endocrine disruption affect health? ​

Abstract ​

Endocrine disruption has emerged as a critical concern in public health and environmental science, encompassing a variety of substances that interfere with the endocrine system, resulting in adverse health outcomes for humans and wildlife. These endocrine disruptors (EDs), prevalent in plastics, pesticides, and personal care products, mimic or block hormones, disrupting the delicate hormonal balance necessary for normal physiological functions. The increasing presence of these chemicals in our environment correlates with a growing body of evidence linking endocrine disruption to health issues such as reproductive disorders, metabolic diseases, and developmental problems, raising significant public health concerns. Understanding the mechanisms of endocrine disruption is essential, as these substances can affect hormone synthesis, transport, and action, leading to profound health impacts. This review synthesizes current knowledge regarding common EDs, their sources, and the health implications associated with exposure, particularly focusing on vulnerable populations like children and pregnant women. Furthermore, it addresses regulatory challenges and identifies gaps in research, calling for comprehensive strategies to mitigate risks. The review concludes by emphasizing the urgent need for interdisciplinary approaches and longitudinal studies to further elucidate the long-term effects of EDs on human health and the environment, ultimately advocating for actions that promote a healthier future.

Outline ​

This report will discuss the following questions.

  • 1 Introduction
  • 2 Understanding Endocrine Disruption
    • 2.1 Definition and Mechanisms of Endocrine Disruption
    • 2.2 Common Endocrine Disruptors and Their Sources
  • 3 Health Impacts of Endocrine Disruption
    • 3.1 Reproductive Health Effects
    • 3.2 Metabolic Disorders and Obesity
    • 3.3 Developmental Effects in Children
  • 4 Vulnerable Populations
    • 4.1 Children and Adolescents
    • 4.2 Pregnant Women
    • 4.3 Occupational Exposure Groups
  • 5 Regulatory Challenges and Public Health Implications
    • 5.1 Current Regulatory Frameworks
    • 5.2 Gaps in Research and Regulation
    • 5.3 Recommendations for Policy Changes
  • 6 Future Directions in Research
    • 6.1 Emerging Endocrine Disruptors
    • 6.2 Longitudinal Studies and Health Monitoring
    • 6.3 Interdisciplinary Approaches to Addressing Endocrine Disruption
  • 7 Conclusion

1 Introduction ​

Endocrine disruption is a significant and growing concern in the field of public health and environmental science, as it encompasses a wide array of substances that can interfere with the endocrine system, leading to adverse health outcomes in both humans and wildlife. These endocrine disruptors (EDs), which can be found in various environmental sources including plastics, pesticides, and personal care products, have the ability to mimic or block hormones, thus disrupting the delicate hormonal balance essential for normal physiological functions. The increasing prevalence of these chemicals in our environment, coupled with a rising body of evidence linking endocrine disruption to a multitude of health issues—ranging from reproductive disorders and metabolic diseases to developmental problems—has raised significant public health concerns and necessitated urgent attention from researchers, policymakers, and healthcare providers [1][2].

The significance of understanding endocrine disruption extends beyond immediate health effects; it encompasses long-term implications for population health and ecological stability. The complexity of endocrine systems, combined with the ubiquity of EDs, presents unique challenges in assessing risks and developing effective regulatory frameworks. Research has shown that exposure to these chemicals can occur through various pathways, including dietary intake, environmental exposure, and occupational hazards, highlighting the need for comprehensive strategies to mitigate their effects [3][4]. Furthermore, the potential for transgenerational effects raises alarming questions about the sustainability of human health in the face of ongoing exposure to EDs [5][6].

Current research indicates that the mechanisms by which EDs exert their effects are multifaceted, involving interactions with hormone receptors and alterations in metabolic pathways [7][8]. For instance, studies have demonstrated that EDs can disrupt reproductive health, contribute to obesity and metabolic disorders, and impair neurodevelopment, particularly in vulnerable populations such as children and pregnant women [9][10]. The evidence suggests that even low-dose exposures during critical developmental windows can have lasting impacts on health [6][11].

This review is organized into several key sections to provide a comprehensive overview of the current state of knowledge regarding endocrine disruption and its health implications. The first section will define endocrine disruption and explore the various mechanisms through which these substances operate, alongside a discussion of common endocrine disruptors and their sources. Following this, we will examine the specific health impacts associated with endocrine disruption, including reproductive health effects, metabolic disorders, and developmental issues in children.

Subsequent sections will focus on identifying vulnerable populations at heightened risk of exposure and adverse effects, such as children, pregnant women, and occupational exposure groups. We will then delve into the regulatory challenges surrounding the management of endocrine disruptors, highlighting current frameworks, gaps in research and regulation, and recommendations for policy changes. Finally, we will outline future directions for research, emphasizing the need for interdisciplinary approaches and longitudinal studies to further elucidate the long-term effects of endocrine disruptors on human health and the environment [4][10].

By synthesizing current knowledge and identifying critical gaps in understanding, this report aims to underscore the urgent need for action in addressing the public health implications of endocrine disruption, ultimately promoting a healthier environment and safeguarding the well-being of future generations.

2 Understanding Endocrine Disruption ​

2.1 Definition and Mechanisms of Endocrine Disruption ​

Endocrine disruption refers to the ability of certain chemicals, known as endocrine disruptors (EDCs), to interfere with the normal functioning of the endocrine system in both humans and wildlife. These disruptors can alter hormone synthesis, secretion, transport, binding, action, or elimination, thereby impacting various physiological processes. The mechanisms through which EDCs exert their effects are multifaceted and involve interactions with hormone receptors, modulation of hormone levels, and disruption of metabolic pathways.

EDCs can originate from both industrial and natural sources and include a wide range of substances such as pesticides, plasticizers, and pharmaceuticals. For instance, compounds like phthalates and bisphenol A are well-known EDCs that can mimic or block hormones, leading to dysregulation of steroid function and metabolism [9]. This dysregulation can have profound effects on various tissues that are sensitive to steroid hormones, including the reproductive system, central nervous system, and thyroid [9].

The impacts of endocrine disruption on health are extensive. Studies have indicated that exposure to EDCs can lead to a variety of adverse health outcomes, including reproductive disorders, developmental defects, and hormone-dependent cancers [6]. For example, prenatal exposure to EDCs has been linked to neurodevelopmental issues, such as attention deficit disorders and mood disorders, which manifest later in life [10]. Furthermore, EDCs can also affect metabolic functions, potentially contributing to obesity and type 2 diabetes [6].

Transgenerational effects are another critical concern associated with endocrine disruptors. Research suggests that EDC exposure can lead to reproductive health issues not only in the exposed individuals but also in subsequent generations [5]. This raises alarms about the long-term implications of EDC exposure, particularly during critical windows of development, such as fetal and perinatal periods [6].

The complexity of EDC interactions is compounded by the fact that these chemicals can exert effects at very low doses and can act in concert with other environmental chemicals, leading to synergistic effects that are difficult to predict [2]. This phenomenon underscores the need for comprehensive assessments of chemical mixtures rather than evaluating individual substances in isolation [11].

Despite the growing body of evidence linking EDCs to adverse health outcomes, many gaps remain in our understanding of the precise mechanisms of action, the extent of human exposure, and the long-term consequences of such exposure [12]. As research continues to evolve, it becomes increasingly crucial to develop effective regulatory frameworks and public health strategies to mitigate the risks associated with endocrine disruptors and protect human health [4].

2.2 Common Endocrine Disruptors and Their Sources ​

Endocrine disruption is a significant area of concern due to its potential impacts on human health and wildlife. Endocrine disruptors (EDs) are compounds that interfere with the normal functioning of the endocrine system, leading to various health issues. These disruptors can be of industrial or natural origin and are capable of modulating hormonal functions, thereby affecting reproductive, metabolic, and neurological health.

A variety of chemicals have been identified as endocrine disruptors, including phthalates, bisphenol A, pesticides, and environmental contaminants such as polychlorinated biphenyls (PCBs) and dioxins. Exposure to these chemicals occurs through multiple pathways, including dietary intake, environmental exposure, and occupational hazards. The ubiquity of these compounds in the environment, found in water, soil, air, and consumer products, raises concerns about chronic exposure and its health implications [1][3][9].

The effects of endocrine disruptors on health can manifest in numerous ways. Research has shown that EDs can lead to reproductive dysfunction, affecting both male and female fertility. For instance, exposure to these chemicals during critical developmental windows, such as prenatal or perinatal periods, can result in transgenerational effects, where the reproductive health of future generations is compromised [5][11]. Moreover, endocrine disruptors have been implicated in the development of hormone-dependent cancers, metabolic disorders, and neurodevelopmental issues [6][10].

Endocrine disruptors can interfere with hormone signaling pathways, leading to dysregulation of steroid hormone functions and metabolism. They may inhibit steroid synthesis and degradation pathways, impacting tissues sensitive to these hormones, such as the reproductive system, thyroid, and even the central nervous system [3][9]. The potential for these compounds to act as epigenetic modulators adds another layer of complexity, as they may induce changes that affect gene expression and health outcomes across generations [6].

Furthermore, the interactions between various endocrine disruptors can produce a "cocktail effect," where the combined exposure to multiple chemicals exacerbates their individual impacts, leading to greater health risks [11]. The mechanisms through which these compounds exert their effects often involve low-dose exposures that can disrupt endocrine homeostasis, potentially resulting in significant health consequences, including developmental disorders, obesity, type 2 diabetes, and neurobehavioral issues [4][7].

In conclusion, the pervasive presence of endocrine disruptors in the environment and their ability to interfere with normal hormonal functions pose serious risks to human health. Ongoing research is critical to fully understand the breadth of their impacts and to develop effective strategies for mitigating exposure and associated health risks [12][13].

3 Health Impacts of Endocrine Disruption ​

3.1 Reproductive Health Effects ​

Endocrine disruptors (EDs) are chemicals that can interfere with the normal functioning of the endocrine system, potentially leading to significant health impacts, particularly concerning reproductive health. The "endocrine disruption hypothesis" posits that exposure to EDs during critical developmental periods—fetal, neonatal, and adult life—can adversely affect the development of reproductive organs, semen quality, and hormone production in humans[14].

The literature provides substantial evidence indicating that EDs can disrupt male reproductive health. For instance, studies have shown that exposure to these chemicals is linked to declines in sperm quality, including reduced sperm count and motility, and increased incidences of reproductive disorders such as infertility and congenital malformations of the male reproductive system[15]. Furthermore, it has been reported that exposure to EDs can have transgenerational effects, meaning that the reproductive health of future generations may also be compromised due to the exposure of ancestors to these chemicals[5].

In females, the impact of EDs is equally concerning. Exposure during adulthood can lead to various reproductive dysfunctions, including subfertility, infertility, and abnormalities in menstrual cycles and hormone production[16]. Specific classes of EDs, such as pesticides and plasticizers, have been identified as particularly harmful to female reproductive health, affecting the hypothalamus, pituitary, ovary, and uterus, which are critical for normal reproductive function[16].

Moreover, the effects of EDs are not limited to direct reproductive outcomes. They can also alter neuroendocrine pathways that influence reproductive health, potentially leading to complications such as delayed puberty and adverse pregnancy outcomes[17]. The complexity of the interactions between various EDs complicates the assessment of their collective impact on reproductive health, as these chemicals can interact synergistically, leading to compounded effects[11].

It is important to note that while animal studies provide strong evidence of the adverse effects of EDs, epidemiological studies in humans often yield conflicting results due to methodological challenges, such as the difficulty in controlling for confounding factors and accurately measuring exposure levels[14]. This highlights the need for well-designed studies to clarify the relationship between ED exposure and reproductive health outcomes in humans.

In summary, endocrine disruptors pose a significant threat to reproductive health in both males and females. Their ability to interfere with hormonal signaling can lead to a range of reproductive disorders, and their effects may extend across generations, necessitating further research to fully understand the implications of ED exposure on human health and to develop strategies to mitigate these risks.

3.2 Metabolic Disorders and Obesity ​

Endocrine disrupting chemicals (EDCs) represent a significant concern in the context of metabolic disorders and obesity. These chemicals, which can interfere with the body's endocrine systems, have been linked to a variety of adverse health effects, particularly concerning metabolic health.

The association between EDCs and metabolic diseases is increasingly recognized. Papalou et al. (2019) indicate that EDCs contribute to the rising prevalence of metabolic diseases, which cannot be solely explained by lifestyle factors such as increased caloric intake and physical inactivity. EDCs exert their effects on critical metabolic organs including the hypothalamus, adipose tissue, pancreatic beta cells, skeletal muscle, and liver, potentially disrupting metabolic processes through epigenetic changes that can be transmitted across generations [18].

Küblbeck et al. (2020) further elaborate on the implications of EDCs, highlighting their role in mimicking, blocking, or interfering with hormones. This interference can lead to metabolic alterations that result in conditions such as obesity, diabetes, and fatty liver disease. Despite the growing body of epidemiological and experimental data linking EDCs to adverse metabolic effects, there remains a lack of predictive methods to evaluate the mechanisms underlying these effects, complicating regulatory risk assessments [19].

Smith et al. (2020) emphasize that obesity, as determined by body mass index (BMI), complicates the clinical evaluation of EDCs. They note that adipose tissue in obese individuals can alter hormone levels, further complicating the understanding of how EDCs might contribute to metabolic disorders. The hormonal perturbations caused by excess adiposity can confound the assessment of EDC effects, necessitating careful consideration of body composition in clinical studies [20].

Moreover, the interference of pollutants with metabolic pathways, particularly through peroxisome proliferator-activated receptors (PPARs), has been identified as a mechanism through which EDCs may contribute to metabolic diseases. Casals-Casas et al. (2008) review evidence showing that certain pollutants disrupt metabolic homeostasis, potentially leading to conditions like obesity and diabetes [21].

The evidence indicates that EDCs pose a multifaceted threat to metabolic health, impacting not only the individual but also having potential transgenerational effects. The complexity of these interactions and the mechanisms involved underline the urgent need for further research to clarify the causal relationships between EDC exposure and metabolic disorders, as well as to develop effective regulatory measures to mitigate these risks.

3.3 Developmental Effects in Children ​

Endocrine-disrupting chemicals (EDCs) have significant implications for health, particularly concerning developmental effects in children. Exposure to these chemicals can lead to a range of neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD), learning disabilities, intellectual disabilities, and autism spectrum disorders. Approximately 12% of children in the United States are affected by such neurodevelopmental disorders, with accumulating evidence suggesting that EDCs may play a role in their etiology by disrupting normal developmental processes during critical periods of growth (Schug et al. 2015) [22].

EDCs can interfere with hormonal signaling pathways and physiological homeostasis, leading to alterations in brain development and function. Gestational exposure to EDCs has been shown to disrupt developmental programs, resulting in long-lasting effects that can extend into adulthood. This disruption can manifest as altered neuroendocrine control, changes in neurotransmitter regulation, and fundamental modifications in behaviors related to learning, memory, and social interactions (Nesan & Kurrasch 2020) [23].

The timing of exposure is critical, as the fetus and young children are particularly vulnerable to the effects of EDCs due to their ongoing developmental processes. Even low doses of these chemicals can have profound impacts, with evidence indicating that prenatal exposure can lead to cognitive and psychomotor developmental issues in children. Research highlights the importance of understanding the potential for EDCs to induce non-communicable diseases and disorders, emphasizing the need for rigorous studies to clarify the effects of prenatal exposure on child development (Toledano et al. 2024) [24].

Furthermore, EDCs have been associated with a range of health issues beyond neurodevelopmental effects. They can disrupt thyroid function, metabolic balance, and immune defenses, further complicating the health landscape for affected children. The transgenerational effects of EDC exposure are also a concern, as evidenced by studies indicating that children exposed in utero may experience psychiatric disorders and other health complications later in life (Sultan et al. 2025) [10].

Overall, the multifaceted impact of EDCs on child health underscores the urgent need for comprehensive research and effective policy measures to mitigate exposure to these harmful substances, particularly during critical developmental windows.

4 Vulnerable Populations ​

4.1 Children and Adolescents ​

Endocrine disruption has significant implications for health, particularly in vulnerable populations such as children and adolescents. Endocrine-disrupting chemicals (EDCs) are known to interfere with the normal functioning of the endocrine system, which can lead to a range of adverse health outcomes. The unique vulnerability of children to these exposures is particularly concerning, as they are in critical stages of development both in utero and during early life.

Research indicates that EDCs can alter fetal development, potentially leading to various disorders that manifest in childhood and later in life. For instance, exposure to EDCs during pregnancy has been associated with neurobehavioral disorders, including psychiatric conditions such as schizophrenia, bipolar disorder, attention deficit disorders, and mood disorders. These outcomes are not only a direct consequence of exposure but may also involve multigenerational and transgenerational effects, where the health impacts extend beyond the initially exposed individuals (Sultan et al., 2025) [10].

In addition to neurodevelopmental issues, EDCs can also affect metabolic processes and immune system function, thereby contributing to non-communicable diseases. A narrative review highlights that EDCs have shown detrimental effects on cognitive and psychomotor development, with some studies indicating sex-specific outcomes in affected children. However, the variability in research findings emphasizes the need for more rigorous investigations to establish clearer associations and inform policy regarding the use of these chemicals (Toledano et al., 2024) [24].

Children are particularly sensitive to low-level exposures to EDCs due to their ongoing developmental processes. The potential programming effects of these chemicals can disrupt neuronal, metabolic, and immune pathways, leading to long-term health consequences. The review of epidemiological studies has revealed that even minimal exposure during critical developmental windows can result in significant health impacts, including alterations in reproductive and renal systems (Ghassabian et al., 2022) [25].

The pervasive presence of EDCs in the environment—through air, water, and food—further complicates the issue, as children are often exposed to these harmful substances from an early age. The implications for child health are profound, necessitating a shift in scientific and policy approaches to mitigate exposure and safeguard the health of future generations (Di Pietro et al., 2023) [26].

In summary, endocrine disruption poses a major threat to the health of children and adolescents, with potential consequences that can affect their physical and mental well-being throughout their lives. Continued research and proactive measures are essential to address the risks associated with EDC exposure and to protect vulnerable populations.

4.2 Pregnant Women ​

Endocrine-disrupting chemicals (EDCs) pose significant health risks, particularly to vulnerable populations such as pregnant women and their offspring. These compounds, prevalent in various environmental and dietary sources, can disrupt the normal functioning of the endocrine system, leading to a range of adverse health outcomes.

Pregnant women are especially susceptible to the effects of EDCs, as their exposure can adversely affect both maternal health and fetal development. The review by Toledano et al. (2024) emphasizes that EDCs can modify the activity of the endocrine system, potentially leading to altered fetal development and an increased risk of various disorders in childhood and adulthood. Research indicates that prenatal exposure to EDCs may have detrimental effects on cognitive and psychomotor development in newborns, as well as a correlation with the emergence of non-communicable diseases later in life[24].

Moreover, the exposure to EDCs during pregnancy has been linked to neurodevelopmental disorders. Sultan et al. (2025) discuss how fetal exposure to EDCs, including synthetic sex hormones, can lead to neurobehavioral issues such as attention deficit disorders and mood disorders, indicating that these substances may also function as neuroendocrine disruptors[10]. The authors highlight the importance of understanding both direct and transgenerational effects of EDCs, underscoring the long-lasting implications of prenatal exposure.

The health impacts of EDCs are not limited to neurodevelopment; they can also affect reproductive health. Research by Sifakis et al. (2017) has shown that exposure to EDCs is associated with disorders in the reproductive system, such as infertility and endometriosis, further emphasizing the critical need for protective measures for pregnant women[27]. The authors note that the complexity of exposure pathways and the structural diversity of EDCs complicate the establishment of direct causal relationships, necessitating more rigorous research.

Additionally, maternal endocrinopathies, such as gestational diabetes, can exacerbate the effects of EDCs during pregnancy. Fox et al. (2025) highlight that conditions like gestational diabetes, which affects 2-16% of pregnancies, can lead to significant complications for both mother and child, including congenital malformations and increased risks for obesity and metabolic disorders later in life[28].

In conclusion, the effects of endocrine disruption during pregnancy can significantly impact both maternal and fetal health. The evidence underscores the necessity for further research to elucidate the mechanisms by which EDCs affect health and to develop policies aimed at minimizing exposure, particularly among vulnerable populations such as pregnant women.

4.3 Occupational Exposure Groups ​

Endocrine disruption, caused by various chemicals known as endocrine disruptors (EDs), poses significant health risks to vulnerable populations, particularly those in occupational exposure groups. These compounds can alter the normal functioning of the endocrine system, which is crucial for regulating various physiological processes, including reproduction, development, and metabolism.

Occupational exposure to EDs can occur in industries where these chemicals are used or produced, leading to higher levels of exposure compared to the general population. The effects of EDs on human health have been extensively documented, with a particular focus on their impact on the reproductive systems of both males and females. Research indicates that exposure to endocrine disrupting chemicals (EDCs) is associated with a range of reproductive disorders, including infertility, endometriosis, and various cancers such as breast and testicular cancer. These disorders are linked to the interference of EDCs with hormone-dependent pathways that govern gonadal development and function, either through direct interaction with hormone receptors or through epigenetic modifications and cell-cycle regulatory mechanisms (Sifakis et al. 2017) [27].

The vulnerability of occupational exposure groups is compounded by several factors. First, the structural diversity of EDCs and their presence at doses below conventional detection limits complicate the assessment of exposure levels and associated health risks. Moreover, the variability in individual susceptibility to EDCs can be influenced by genetic, hormonal, and environmental factors, further complicating the establishment of causal relationships between exposure and health outcomes (Kabir et al. 2015) [1].

In addition to reproductive health, EDCs can also affect other steroid-sensitive tissues, including the thyroid and central nervous system. Studies have shown that these compounds can disrupt thyroid function and modulate immune responses, potentially leading to broader health implications, including metabolic disorders and neurodevelopmental issues (Waring & Harris 2011) [9].

Furthermore, the long-term effects of occupational exposure to EDCs are not yet fully understood, and there is a pressing need for comprehensive studies that standardize the assessment of exposure and its direct effects on health. Current methodologies often lack uniformity, which hampers the ability to draw definitive conclusions regarding the risks posed by EDCs in occupational settings (Juberg 2000) [29].

In summary, endocrine disruption through occupational exposure to EDCs significantly impacts health, particularly in vulnerable populations. The consequences include reproductive disorders, potential developmental issues, and a range of other health effects that necessitate further investigation and the establishment of preventive measures to protect those at risk.

5 Regulatory Challenges and Public Health Implications ​

5.1 Current Regulatory Frameworks ​

Endocrine disruption poses significant threats to human health, impacting various physiological systems and leading to a range of health issues. Endocrine disruptors (EDs) are chemicals that can interfere with the normal functioning of the endocrine system, which regulates hormones crucial for numerous bodily functions. The effects of these disruptors can be profound, affecting reproductive health, metabolic processes, and even neurological functions.

One of the most critical areas affected by endocrine disruption is reproductive health. EDs have been implicated in alterations to the male reproductive tract, female gynecological systems, and overall human fertility. They can also disrupt thyroid function, which is vital for metabolic regulation and development, particularly during critical periods such as fetal and perinatal stages (Mendes 2002; Fenichel et al. 2016). The exposure to these chemicals during sensitive developmental windows can lead to long-term consequences, including developmental and reproductive defects, and hormone-dependent cancers (Fenichel et al. 2016).

In addition to reproductive and thyroid impacts, EDs have been linked to neurodevelopmental and neurodegenerative diseases. Evidence suggests that exposure to endocrine disruptors can lead to psychiatric disorders, attention deficit disorders, and mood disorders, particularly when exposure occurs in utero (Sultan et al. 2025). The neuroendocrine effects of these chemicals highlight their ability to alter brain development and function, which may have transgenerational consequences.

The risk posed by endocrine disruptors is compounded by their ubiquity in the environment, as they can be found in various sources, including food, water, and air. They can bioaccumulate in the body, leading to chronic exposure, which is particularly concerning for vulnerable populations such as pregnant women and children (Kabir et al. 2015). Furthermore, the "cocktail effect"—the potential for multiple chemicals to interact synergistically—adds another layer of complexity to assessing risks associated with these substances.

Regulatory frameworks surrounding endocrine disruptors face significant challenges. Despite growing awareness of their health implications, there is still a lack of comprehensive regulations to manage exposure and mitigate risks. Current assessments often do not adequately account for the long-term effects of low-dose exposures or the cumulative impacts of multiple chemicals. There is an urgent need for tighter regulations and more robust public health strategies to address the pervasive nature of these disruptors and their associated health risks (Waring & Harris 2011; Rizan et al. 2025).

In conclusion, endocrine disruption represents a multifaceted public health challenge that requires urgent attention. The health implications are broad, affecting reproductive health, metabolic processes, and neurological functions, with significant risks during critical developmental periods. Regulatory efforts must evolve to better protect public health by addressing the complexities associated with endocrine disruptors.

5.2 Gaps in Research and Regulation ​

Endocrine disruption represents a significant public health challenge due to its potential to interfere with the normal functioning of the endocrine system, which regulates various physiological processes through hormones. Endocrine disruptors (EDs), which can be of both natural and synthetic origins, have been linked to a variety of adverse health effects, including reproductive issues, developmental defects, metabolic disorders, and hormone-dependent cancers [3][6][9].

The mechanisms by which EDs exert their effects are complex and multifaceted. They can modulate steroid hormone functions and metabolism, affecting reproductive health, thyroid function, and even neurological development [9]. The disruption can occur through several pathways, including the inhibition of steroid synthesis and degradation, as well as the alteration of hormonal signaling pathways. Notably, EDs can act as agonists or antagonists of steroid receptors, thereby dysregulating normal hormonal activities [7][9].

Research has indicated that exposure to EDs during critical developmental windows, such as fetal, perinatal, and peri-pubertal periods, may lead to long-term health consequences, including neurodevelopmental disorders and reproductive health issues [10]. Moreover, chronic exposure to low doses of these chemicals, particularly through environmental sources such as water, air, and food, raises concerns about cumulative effects and potential synergistic interactions among multiple EDs [6][7].

Despite the increasing body of evidence linking EDs to health risks, significant gaps remain in our understanding and regulation of these substances. The complexity of endocrine disruption, characterized by non-monotonic dose-response relationships and varying effects based on exposure timing and context, complicates risk assessment and regulatory frameworks [13][30]. The lack of standardized testing methods and validated biomarkers for assessing exposure and effects further hinders regulatory efforts. Consequently, there is a pressing need for harmonized guidelines and comprehensive research to address these gaps, facilitate better risk assessment, and inform public health policies [30].

The consensus reached by a group of international scientists emphasizes the necessity for a coordinated approach to the regulation of EDs, highlighting the importance of understanding the scientific principles underlying ED identification and the challenges posed by uncertainties in exposure assessment and risk evaluation [30]. As such, the development of effective regulatory measures is essential to mitigate the health impacts of endocrine disruption and protect both human and environmental health.

5.3 Recommendations for Policy Changes ​

Endocrine disruption is a significant concern for public health, as it can lead to a range of adverse health effects in both humans and wildlife. Endocrine disruptors (EDs) are chemicals that interfere with the normal functioning of the endocrine system, which regulates various physiological processes through hormones. These compounds can be of industrial or natural origin and have been linked to various health issues, including reproductive dysfunction, metabolic disorders, and neurodevelopmental alterations.

The implications of endocrine disruption on health are multifaceted. Research indicates that EDs can disrupt steroid hormone function and metabolism, affecting not only reproductive health but also other steroid-sensitive tissues such as the central nervous system and thyroid. For instance, studies have shown that EDs can influence immune system function and glucose homeostasis, with potential transgenerational effects due to their epigenetic modulation capabilities (Waring & Harris, 2011; Solecki et al., 2017). Moreover, exposure to these chemicals has been associated with an increased risk of hormone-sensitive cancers and various reproductive health issues, such as declining sperm counts and female gynecological disorders (Mendes, 2002).

The regulatory challenges surrounding endocrine disruptors stem from the complexities involved in their identification and risk assessment. The lack of consensus on definitions and scientific principles for identifying EDs complicates regulatory frameworks (Solecki et al., 2017). Furthermore, the assessment of risks posed by EDs is complicated by factors such as non-monotonic dose-response relationships, which indicate that the effects of EDs do not always correlate with the dose, and the difficulty in accurately reconstructing exposure histories (Solecki et al., 2017).

Given these challenges, several recommendations for policy changes can be made to better address the public health implications of endocrine disruption. Firstly, it is essential to harmonize guidelines for the regulation of EDs, establishing clear definitions and criteria for their identification. This could involve developing standardized testing methods that accurately assess the endocrine activity of various substances while considering the nuances of dose-response relationships (Solecki et al., 2017).

Additionally, increasing public awareness about the potential health risks associated with EDs is crucial. Educational initiatives can help inform individuals about the sources of exposure, such as plastics containing phthalates and bisphenol A, which are prevalent in everyday products (Weiss, 2012). Policymakers should also advocate for the reduction of harmful substances in consumer products, promoting the use of safer alternatives and encouraging manufacturers to adopt practices that minimize environmental contamination.

Finally, interdisciplinary collaboration among scientists, regulators, and public health officials is necessary to develop comprehensive strategies for monitoring and mitigating the effects of endocrine disruptors. This collaboration should focus on integrating research findings into regulatory frameworks and public health policies to ensure that they are responsive to emerging evidence regarding the health impacts of EDs (Kabir et al., 2015).

In conclusion, endocrine disruption poses significant health risks that require urgent attention from policymakers and public health officials. By addressing regulatory challenges and implementing evidence-based recommendations, it is possible to mitigate the adverse effects of endocrine disruptors on human health and the environment.

6 Future Directions in Research ​

6.1 Emerging Endocrine Disruptors ​

Endocrine disruption poses significant risks to human health through the interference with normal hormonal functions. This disruption can lead to a variety of adverse health outcomes, including reproductive issues, developmental defects, and increased susceptibility to hormone-dependent cancers. Endocrine disruptors (EDs) are chemicals that can mimic or interfere with the body’s hormones, affecting not only reproductive functions but also influencing a range of tissues sensitive to steroid hormones, such as the central nervous system and thyroid [9].

The potential impacts of endocrine disruptors on human health have been extensively documented, indicating that these compounds can alter homeostasis, reproduction, and behavior. The effects are particularly concerning due to their ability to cause transgenerational changes, which means that exposure can affect not only the individuals directly exposed but also their descendants [6]. For instance, low-dose exposure during critical developmental windows, such as fetal and perinatal periods, has been linked to various health issues, including neurodevelopmental disorders and metabolic diseases [4][6].

Emerging research has highlighted the need for better understanding of the mechanisms by which endocrine disruptors exert their effects. For example, studies have indicated that these chemicals can modulate endocrine and immune systems, leading to alterations in reproductive health, thyroid function, and even behaviors [3][7]. The complexity of these interactions is compounded by the presence of multiple EDs in the environment, which can act synergistically to exacerbate health effects [11].

Future directions in research must focus on several critical areas. First, there is a pressing need for improved methodologies to assess the long-term health impacts of EDs, particularly in human populations. This includes addressing significant data gaps regarding the epidemiological links between ED exposure and specific health outcomes [12]. Furthermore, researchers must explore the combined effects of multiple EDs, as the cocktail effect may result in health consequences that are not evident when studying individual compounds in isolation [11].

Additionally, it is essential to investigate the role of dietary and environmental factors in modulating the effects of endocrine disruptors. For instance, certain dietary components, such as phytoestrogens found in soy, may interact with EDs and influence their effects on health [8]. Understanding these interactions will help in developing guidelines for safer dietary practices, especially for vulnerable populations like infants and children [8].

Finally, regulatory frameworks need to evolve to address the complexities of endocrine disruption. This includes implementing stricter regulations on known EDs and promoting research into alternative materials with lower toxicity profiles [4]. As the scientific community continues to unravel the intricacies of endocrine disruption, a multidisciplinary approach combining toxicology, epidemiology, and environmental science will be crucial for mitigating risks to human health.

6.2 Longitudinal Studies and Health Monitoring ​

Endocrine disruption poses significant risks to human health, influencing various physiological systems and potentially leading to chronic diseases. Endocrine disruptors (EDCs) are chemicals that interfere with the normal functioning of the endocrine system, affecting hormone regulation and signaling pathways. The impacts of EDCs on health can be profound, leading to reproductive disorders, metabolic diseases, neurodevelopmental issues, and even hormone-dependent cancers.

Research indicates that exposure to EDCs can disrupt reproductive functions in both males and females, affecting fertility and leading to developmental defects. For instance, studies have highlighted that EDCs such as phthalates and bisphenol A are associated with negative reproductive outcomes, including transgenerational effects that may compromise the reproductive health of future generations (Brehm and Flaws 2019) [5]. Additionally, the timing of exposure is critical; low-dose exposure during sensitive developmental windows, such as fetal and perinatal periods, can have lasting impacts on reproductive health (Fenichel et al. 2016) [6].

Metabolic disorders, including obesity and type 2 diabetes, have also been linked to EDC exposure. These chemicals can interfere with metabolic pathways and hormone signaling, leading to disturbances in glucose and fat metabolism (Swedenborg et al. 2009) [7]. The mechanisms through which EDCs exert their effects often involve the modulation of nuclear receptors and other signaling pathways, illustrating the complexity of their action (Fenichel et al. 2016) [6].

Neurodevelopmental effects are another area of concern. Exposure to EDCs during critical periods of brain development can lead to neurobehavioral disorders, including attention deficit disorders and mood disorders (Sultan et al. 2025) [10]. The potential for these effects to be transgenerational raises significant public health concerns, as they may affect not just individuals but entire populations.

Given the pervasive nature of EDCs in the environment, monitoring and longitudinal studies are essential for understanding their long-term health impacts. Current research efforts emphasize the need for comprehensive health monitoring and the establishment of robust epidemiological studies to better assess the effects of EDCs on human health (FitzGerald 2020) [12]. Such studies can help identify critical exposure periods and elucidate the mechanisms by which EDCs contribute to various health outcomes.

In summary, the effects of endocrine disruption on health are multifaceted, affecting reproductive health, metabolic processes, and neurodevelopment. The complexity of these interactions necessitates ongoing research, particularly longitudinal studies that can track health outcomes over time and inform public health strategies aimed at mitigating the risks associated with EDC exposure.

6.3 Interdisciplinary Approaches to Addressing Endocrine Disruption ​

Endocrine disruption is a critical area of research that addresses how certain chemicals, known as endocrine-disrupting chemicals (EDCs), interfere with hormonal systems, potentially leading to various adverse health outcomes. These compounds can originate from industrial sources or occur naturally and are known to disrupt the normal functioning of the endocrine system in both humans and wildlife. The implications of this disruption are profound, affecting reproductive health, metabolic functions, immune responses, and neurological development.

The effects of EDCs on health are multifaceted. For instance, exposure to these chemicals has been linked to reproductive disorders, including developmental and reproductive defects, hormone-dependent cancers, and metabolic diseases such as obesity and type 2 diabetes. Studies suggest that low-dose exposures during critical developmental windows, such as fetal and perinatal periods, may have particularly detrimental effects, leading to transgenerational impacts on health (Fenichel et al. 2016; Brehm & Flaws 2019) [5][6].

The complexity of interactions between EDCs and biological systems is further compounded by the ubiquitous nature of these chemicals in the environment, which can lead to simultaneous exposure to multiple EDCs, creating a "cocktail effect" that complicates risk assessment (Dutta et al. 2023) [11]. Furthermore, EDCs can interfere with gene expression at very low concentrations, affecting not only individual organisms but potentially entire populations over time (Anwer et al. 2016) [2].

Future research directions in the field of endocrine disruption must adopt interdisciplinary approaches to better understand the mechanisms of action of EDCs and their long-term health implications. Integrating insights from toxicology, epidemiology, molecular biology, and environmental science will be crucial in addressing the complexities of EDC exposure and its effects. The need for comprehensive epidemiological studies that link environmental exposure data with health outcomes is paramount, as many existing studies have significant weaknesses, including issues with exposure assessment and data governance (FitzGerald 2020) [12].

Moreover, establishing standardized methodologies for assessing the risks associated with EDCs is essential. This includes developing robust screening methods for EDCs at molecular and cellular levels and expanding research on the interactions between EDCs and various biological pathways (Daston et al. 2003) [31]. As the field progresses, collaborative efforts among scientists, regulatory bodies, and public health organizations will be vital in formulating effective strategies to mitigate the risks posed by EDCs and to promote healthier environments for future generations.

In conclusion, understanding the health impacts of endocrine disruption requires a concerted effort across disciplines to elucidate the mechanisms by which EDCs affect human health, assess their risks accurately, and develop informed policies to reduce exposure.

7 Conclusion ​

The findings presented in this review highlight the significant and multifaceted health impacts of endocrine disruptors (EDs), which interfere with the normal functioning of the endocrine system. Key discoveries indicate that EDs are linked to reproductive health issues, metabolic disorders, and neurodevelopmental effects, particularly in vulnerable populations such as children and pregnant women. The current state of research reveals gaps in understanding the precise mechanisms of action, exposure pathways, and long-term health consequences associated with EDs. Future research directions should focus on interdisciplinary approaches, emphasizing the need for longitudinal studies to monitor health outcomes and the establishment of comprehensive regulatory frameworks. Policymakers must prioritize the development of effective strategies to mitigate exposure to EDs, ensuring the protection of public health and the environment. By addressing these challenges, we can work towards safeguarding the well-being of future generations against the adverse effects of endocrine disruption.

References ​

  • [1] Eva Rahman Kabir;Monica Sharfin Rahman;Imon Rahman. A review on endocrine disruptors and their possible impacts on human health.. Environmental toxicology and pharmacology(IF=4.2). 2015. PMID:26164742. DOI: .
  • [2] Faizan Anwer;Savita Chaurasia;Abid Ali Khan. Hormonally active agents in the environment: a state-of-the-art review.. Reviews on environmental health(IF=4.5). 2016. PMID:27487487. DOI: .
  • [3] J J Amaral Mendes. The endocrine disrupters: a major medical challenge.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association(IF=3.5). 2002. PMID:11983272. DOI: 10.1016/s0278-6915(02)00018-2.
  • [4] Chantelle Rizan;Jeanette M Rotchell;Pei Chia Eng;Bernard Robaire;Corina Ciocan;Nitin Kapoor;Sanjay Kalra;Jodi D Sherman. Mitigating the environmental effects of healthcare: the role of the endocrinologist.. Nature reviews. Endocrinology(IF=40.0). 2025. PMID:40082727. DOI: 10.1038/s41574-025-01098-9.
  • [5] Emily Brehm;Jodi A Flaws. Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction.. Endocrinology(IF=3.3). 2019. PMID:30998239. DOI: 10.1210/en.2019-00034.
  • [6] Patrick Fenichel;Françoise Brucker-Davis;Nicolas Chevalier. [Endocrine disruptors, reproduction and hormone-dependent cancers].. Presse medicale (Paris, France : 1983)(IF=3.4). 2016. PMID:26655259. DOI: .
  • [7] Elin Swedenborg;Joëlle Rüegg;Sari Mäkelä;Ingemar Pongratz. Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders.. Journal of molecular endocrinology(IF=3.8). 2009. PMID:19211731. DOI: 10.1677/JME-08-0132.
  • [8] Heather B Patisaul. Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.. The Proceedings of the Nutrition Society(IF=4.5). 2017. PMID:27389644. DOI: 10.1017/S0029665116000677.
  • [9] R H Waring;R M Harris. Endocrine disrupters--a threat to women's health?. Maturitas(IF=3.6). 2011. PMID:21075568. DOI: 10.1016/j.maturitas.2010.10.008.
  • [10] Charles Sultan;Laura Gaspari;Marie-Odile Soyer-Gobillard. Effects of Endocrine-Disrupting Chemicals in the Brain: The Example of Neurodevelopment Alterations upon Exposure In Utero to Synthetic Sex Hormones.. Journal of xenobiotics(IF=4.4). 2025. PMID:41149748. DOI: 10.3390/jox15050162.
  • [11] Sulagna Dutta;Pallav Sengupta;Sovan Bagchi;Bhupender S Chhikara;Aleš Pavlík;Petr Sláma;Shubhadeep Roychoudhury. Reproductive toxicity of combined effects of endocrine disruptors on human reproduction.. Frontiers in cell and developmental biology(IF=4.3). 2023. PMID:37250900. DOI: 10.3389/fcell.2023.1162015.
  • [12] Rex E FitzGerald. Perspective on Health Effects of Endocrine Disruptors with a Focus on Data Gaps.. Chemical research in toxicology(IF=3.8). 2020. PMID:32250608. DOI: 10.1021/acs.chemrestox.9b00529.
  • [13] T M Crisp;E D Clegg;R L Cooper;W P Wood;D G Anderson;K P Baetcke;J L Hoffmann;M S Morrow;D J Rodier;J E Schaeffer;L W Touart;M G Zeeman;Y M Patel. Environmental endocrine disruption: an effects assessment and analysis.. Environmental health perspectives(IF=9.8). 1998. PMID:9539004. DOI: 10.1289/ehp.98106s111.
  • [14] D Bliatka;S Lymperi;G Mastorakos;D G Goulis. Effect of endocrine disruptors on male reproduction in humans: why the evidence is still lacking?. Andrology(IF=3.4). 2017. PMID:28296338. DOI: 10.1111/andr.12339.
  • [15] Andrea Di Nisio;Carlo Foresta. Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility.. Reproductive biology and endocrinology : RB&E(IF=4.7). 2019. PMID:30611299. DOI: 10.1186/s12958-018-0449-4.
  • [16] Saniya Rattan;Changqing Zhou;Catheryne Chiang;Sharada Mahalingam;Emily Brehm;Jodi A Flaws. Exposure to endocrine disruptors during adulthood: consequences for female fertility.. The Journal of endocrinology(IF=3.9). 2017. PMID:28356401. DOI: 10.1530/JOE-17-0023.
  • [17] Heather B Patisaul. REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.. Reproduction (Cambridge, England)(IF=3.7). 2021. PMID:33929341. DOI: 10.1530/REP-20-0596.
  • [18] Olga Papalou;Eleni A Kandaraki;George Papadakis;Evanthia Diamanti-Kandarakis. Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease.. Frontiers in endocrinology(IF=4.6). 2019. PMID:30881345. DOI: 10.3389/fendo.2019.00112.
  • [19] Jenni Küblbeck;Taina Vuorio;Jonna Niskanen;Vittorio Fortino;Albert Braeuning;Khaled Abass;Arja Rautio;Jukka Hakkola;Paavo Honkakoski;Anna-Liisa Levonen. The EDCMET Project: Metabolic Effects of Endocrine Disruptors.. International journal of molecular sciences(IF=4.9). 2020. PMID:32344727. DOI: 10.3390/ijms21083021.
  • [20] Carr J Smith;Thomas A Perfetti;A Wallace Hayes;Sir Colin Berry. Clinical epidemiology studies on potential effects of endocrine disrupting chemicals (EDCs) should exclude subjects with obesity as determined by BMI.. Regulatory toxicology and pharmacology : RTP(IF=3.5). 2020. PMID:32598900. DOI: 10.1016/j.yrtph.2020.104711.
  • [21] C Casals-Casas;J N Feige;B Desvergne. Interference of pollutants with PPARs: endocrine disruption meets metabolism.. International journal of obesity (2005)(IF=3.8). 2008. PMID:19079281. DOI: 10.1038/ijo.2008.207.
  • [22] Thaddeus T Schug;Ashley M Blawas;Kimberly Gray;Jerrold J Heindel;Cindy P Lawler. Elucidating the links between endocrine disruptors and neurodevelopment.. Endocrinology(IF=3.3). 2015. PMID:25714811. DOI: 10.1210/en.2014-1734.
  • [23] Dinushan Nesan;Deborah M Kurrasch. Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior.. Annual review of physiology(IF=19.1). 2020. PMID:31738670. DOI: 10.1146/annurev-physiol-021119-034555.
  • [24] Juan M Toledano;Maria Puche-Juarez;Jorge Moreno-Fernandez;Patricia Gonzalez-Palacios;Ana Rivas;Julio J Ochoa;Javier Diaz-Castro. Implications of Prenatal Exposure to Endocrine-Disrupting Chemicals in Offspring Development: A Narrative Review.. Nutrients(IF=5.0). 2024. PMID:38892490. DOI: 10.3390/nu16111556.
  • [25] Akhgar Ghassabian;Laura Vandenberg;Kurunthachalam Kannan;Leonardo Trasande. Endocrine-Disrupting Chemicals and Child Health.. Annual review of pharmacology and toxicology(IF=13.1). 2022. PMID:34555290. DOI: 10.1146/annurev-pharmtox-021921-093352.
  • [26] Giada Di Pietro;Francesca Forcucci;Francesco Chiarelli. Endocrine Disruptor Chemicals and Children's Health.. International journal of molecular sciences(IF=4.9). 2023. PMID:36768991. DOI: 10.3390/ijms24032671.
  • [27] Stavros Sifakis;Vasilis P Androutsopoulos;Aristeidis M Tsatsakis;Demetrios A Spandidos. Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems.. Environmental toxicology and pharmacology(IF=4.2). 2017. PMID:28292651. DOI: 10.1016/j.etap.2017.02.024.
  • [28] Ruth Fox;Su'ad Akinboro;Andrzej Kędzia;Elżbieta Niechciał. The Effects of Maternal Endocrinopathies and Exposure to Endocrine Disruptors During Pregnancy on the Fetus and Newborn.. Biomedicines(IF=3.9). 2025. PMID:40868219. DOI: 10.3390/biomedicines13081965.
  • [29] D R Juberg. An evaluation of endocrine modulators: implications for human health.. Ecotoxicology and environmental safety(IF=6.1). 2000. PMID:10648129. DOI: 10.1006/eesa.1999.1851.
  • [30] Roland Solecki;Andreas Kortenkamp;Åke Bergman;Ibrahim Chahoud;Gisela H Degen;Daniel Dietrich;Helmut Greim;Helen Håkansson;Ulla Hass;Trine Husoy;Miriam Jacobs;Susan Jobling;Alberto Mantovani;Philip Marx-Stoelting;Aldert Piersma;Vera Ritz;Remy Slama;Ralf Stahlmann;Martin van den Berg;R Thomas Zoeller;Alan R Boobis. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.. Archives of toxicology(IF=6.9). 2017. PMID:27714423. DOI: 10.1007/s00204-016-1866-9.
  • [31] George P Daston;Jon C Cook;Robert J Kavlock. Uncertainties for endocrine disrupters: our view on progress.. Toxicological sciences : an official journal of the Society of Toxicology(IF=4.1). 2003. PMID:12730617. DOI: 10.1093/toxsci/kfg105.

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