MaltSci 麦伴科研

Appearance

文献精选 > 近年高分"阿尔茨海默病"研究（IF≥30，近5年）

Cervical cancer prevention and control in women living with human immunodeficiency virus. ​

文献信息 ​

DOI10.3322/caac.21696
PMID34499351
期刊CA: a cancer journal for clinicians
影响因子232.4
JCR 分区Q1
发表年份2021
被引次数92
关键词非洲，宫颈癌，细胞学，人类免疫缺陷病毒（HIV），人类乳头瘤病毒（HPV）
文献类型Journal Article, Research Support, N.I.H., Extramural, Review
ISSN0007-9235
页码505-526
期号71(6)
作者Philip E Castle, Mark H Einstein, Vikrant V Sahasrabuddhe

一句话小结 ​

本研究评估了HIV感染对宫颈癌风险的影响，指出HIV感染女性因免疫反应受损而面临更高的宫颈癌风险，特别是在低收入国家。作者强调整合HIV护理与宫颈癌预防控制措施的重要性，以推动全球消除宫颈癌作为公共卫生问题的努力。

在麦伴科研 (maltsci.com) 搜索更多文献 ​

非洲 · 宫颈癌 · 细胞学 · 人类免疫缺陷病毒（HIV） · 人类乳头瘤病毒（HPV）

摘要 ​

尽管宫颈癌是高度可预防的，但它仍然是全球女性中第四常见的癌症和癌症死亡的主要原因。在低收入国家，宫颈癌往往是癌症相关发病率和死亡率的主要原因。生活在 HIV（人类免疫缺陷病毒）/艾滋病（获得性免疫缺陷综合症）感染下的女性，因其对人乳头状瘤病毒的免疫反应受损，面临着特别高的宫颈癌风险，而人乳头状瘤病毒几乎是所有宫颈癌的必然原因。全球约每20例宫颈癌中就有1例与HIV有关；在撒哈拉以南非洲，约每5例宫颈癌中就有1例是由于HIV引起的。本文的作者对迄今为止HIV疾病对宫颈癌风险的影响证据进行了批判性评估，描述了主要的方法学问题，并提出了关键的未解研究问题，特别是这些问题如何适用于正在进行的全球宫颈癌预防和控制努力。扩大HIV护理与宫颈癌预防和控制的整合努力，反之亦然，可能有助于全球消除宫颈癌作为公共卫生问题的努力。

英文摘要 ​

Despite being highly preventable, cervical cancer is the fourth most common cancer and cause of cancer death in women globally. In low-income countries, cervical cancer is often the leading cause of cancer-related morbidity and mortality. Women living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome are at a particularly high risk of cervical cancer because of an impaired immune response to human papillomavirus, the obligate cause of virtually all cervical cancers. Globally, approximately 1 in 20 cervical cancers is attributable to HIV; in sub-Saharan Africa, approximately 1 in 5 cervical cancers is due to HIV. Here, the authors provide a critical appraisal of the evidence to date on the impact of HIV disease on cervical cancer risk, describe key methodologic issues, and frame the key outstanding research questions, especially as they apply to ongoing global efforts for prevention and control of cervical cancer. Expanded efforts to integrate HIV care with cervical cancer prevention and control, and vice versa, could assist the global effort to eliminate cervical cancer as a public health problem.

麦伴智能科研服务 ​

智能阅读回答你对文献的任何问题，帮助理解文献中的复杂图表和公式
定位观点定位某个观点在文献中的蛛丝马迹
加入知识库完成数据提取，报告撰写等更多高级知识挖掘功能

主要研究问题 ​

  1. 在HIV感染女性中，针对宫颈癌的预防措施有哪些具体的实施策略？
  2. 如何评估HIV与宫颈癌之间的关系在不同人群中的差异？
  3. 在低收入国家，哪些因素影响HIV感染女性的宫颈癌筛查和治疗的可及性？
  4. 当前有哪些新兴技术或方法可以提高HIV阳性女性的宫颈癌早期检测率？
  5. 如何有效整合HIV护理与宫颈癌预防控制的服务，以提高公共卫生效果？

核心洞察 ​

研究背景和目的 ​

宫颈癌是全球女性中第四大常见癌症，尽管可以预防，但在低收入国家中，宫颈癌仍然是癌症相关的主要发病和死亡原因。生活在HIV/AIDS环境中的女性因免疫系统受损，面临更高的宫颈癌风险。本文旨在评估HIV对宫颈癌风险的影响，探讨相关的预防和控制策略，并提出未来的研究方向。

主要方法/材料/实验设计 ​

研究采用文献回顾和数据分析的方法，聚焦于以下几个方面：

  1. HIV与宫颈癌的流行病学：分析HIV感染者中宫颈癌的发病率与非感染者的比较。
  2. HPV疫苗接种与筛查策略：探讨在HIV阳性女性中实施HPV疫苗接种和宫颈癌筛查的有效性。
  3. 临床管理与治疗：研究HIV感染对宫颈癌治疗结果的影响。

以下是技术路线的Mermaid代码：

Mermaid diagram

关键结果和发现 ​

  1. 流行病学数据：HIV阳性女性的宫颈癌发病率约为HIV阴性女性的6倍，且在低收入国家中这一比例更高。
  2. 疫苗接种效果：HPV疫苗在HIV阳性女性中表现出良好的免疫应答，尽管免疫力与HIV病毒载量和CD4细胞计数有关。
  3. 筛查策略：HPV DNA检测比传统的Pap涂片检测在宫颈癌筛查中更有效，尤其是在HIV阳性女性中。
  4. 治疗结果：HIV感染女性在宫颈癌治疗中更可能出现复发，且治疗效果与CD4计数和病毒抑制水平密切相关。

主要结论/意义/创新性 ​

本研究强调了HIV与宫颈癌之间的密切关系，提出通过整合HIV护理与宫颈癌预防策略，可以有效降低宫颈癌的发生率。研究还指出，优化HIV管理将直接改善宫颈癌筛查和治疗效果，特别是在资源有限的环境中。

研究局限性和未来方向 ​

  • 局限性：本研究主要依赖现有文献，缺乏长期的前瞻性研究数据。
  • 未来方向：
    1. 需要开展大规模的前瞻性研究，以评估HIV管理对宫颈癌风险的长期影响。
    2. 探索在低收入国家实施有效的HPV疫苗接种和筛查策略的可行性。
    3. 加强对HIV阳性女性的临床监测和随访，以提高宫颈癌的早期发现率和治疗效果。

参考文献 ​

  1. Update of Survival for Persons With HIV Infection in Denmark. - Nicolai Lohse;Niels Obel - Annals of internal medicine (2016)
  2. WHO Launches Global Push to Eliminate Cervical Cancer. - Bridget M Kuehn - JAMA (2021)
  3. Use of a 2-Dose Schedule for Human Papillomavirus Vaccination - Updated Recommendations of the Advisory Committee on Immunization Practices. - Elissa Meites;Allison Kempe;Lauri E Markowitz - MMWR. Morbidity and mortality weekly report (2016)
  4. Telementoring in gynecologic oncology training: changing lives in Mozambique. - Renato Moretti-Marques;Mila Pontremoli Salcedo;Donato Callegaro Filho;Andre Lopes;Marcelo Vieira;Geórgia Fontes Cintra;Magda Ribeiro;Dércia Changule;Siro Daud;Ricardina Rangeiro;Ellen Baker;Cesaltina Lorenzoni;Jose Humberto Tavares Guerreiro Fregnani;Kathleen M Schmeler - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2020)
  5. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence. - Susanne K Kjær;Kirsten Frederiksen;Christian Munk;Thomas Iftner - Journal of the National Cancer Institute (2010)
  6. Prevalence of high-risk HPV genotypes in sub-Saharan Africa according to HIV status: a 20-year systematic review. - Jude Ogechukwu Okoye;Chukwudi Amaechi Ofodile;Oluwaseun Kelechi Adeleke;Okechi Obioma - Epidemiology and health (2021)
  7. Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis. - Helen Kelly;Helen A Weiss;Yolanda Benavente;Silvia de Sanjose;Philippe Mayaud; - The lancet. HIV (2018)
  8. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. - Marc Arbyn;Sara B Smith;Sarah Temin;Farhana Sultana;Philip Castle; - BMJ (Clinical research ed.) (2018)
  9. Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial. - Aimée R Kreimer;Joshua N Sampson;Carolina Porras;John T Schiller;Troy Kemp;Rolando Herrero;Sarah Wagner;Joseph Boland;John Schussler;Douglas R Lowy;Stephen Chanock;David Roberson;Mónica S Sierra;Sabrina H Tsang;Mark Schiffman;Ana Cecilia Rodriguez;Bernal Cortes;Mitchell H Gail;Allan Hildesheim;Paula Gonzalez;Ligia A Pinto; - Journal of the National Cancer Institute (2020)
  10. Age-specific occurrence of HPV16- and HPV18-related cervical cancer. - Silvia de Sanjose;Cosette M Wheeler;Wim G V Quint;William C Hunt;Nancy E Joste;Laia Alemany;F Xavier Bosch; ;Evan R Myers;Philip E Castle - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2013)

引用本文的文献 ​

  1. Cervical cancer prevention and control in women living with human immunodeficiency virus. - Philip E Castle;Mark H Einstein;Vikrant V Sahasrabuddhe - CA: a cancer journal for clinicians (2021)
  2. Development and Validation of Novel Nomograms to Predict the Overall Survival and Cancer-Specific Survival of Cervical Cancer Patients With Lymph Node Metastasis. - Jianying Yi;Zhili Liu;Lu Wang;Xingxin Zhang;Lili Pi;Chunlei Zhou;Hong Mu - Frontiers in oncology (2022)
  3. Development and Validation of a Nomogram for Predicting Postoperative Distant Metastasis in Patients with Cervical Cancer. - Weihong Zeng;Lishan Huang;Haihong Lin;Ru Pan;Haochang Liu;Jizhong Wen;Ye Liang;Haikun Yang - Medical science monitor : international medical journal of experimental and clinical research (2022)
  4. Everolimus (RAD001) combined with programmed death-1 (PD-1) blockade enhances radiosensitivity of cervical cancer and programmed death-ligand 1 (PD-L1) expression by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) pathway. - Lili Song;Shikai Liu;Sufen Zhao - Bioengineered (2022)
  5. Update on the Epidemiological Features and Clinical Implications of Human Papillomavirus Infection (HPV) and Human Immunodeficiency Virus (HIV) Coinfection. - Alexandre Pérez-González;Edward Cachay;Antonio Ocampo;Eva Poveda - Microorganisms (2022)
  6. The Modeling Analysis and Effect of CHI3L1 and CD31-Marked Microvessel Density in the Occurrence and Development of Cervical Squamous Cell Carcinoma. - Yanzi Qin;Wenjun Zhao - Computational and mathematical methods in medicine (2022)
  7. It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer. - Mallory G McKeon;Jean-Nicolas Gallant;Young J Kim;Suman R Das - Cancers (2022)
  8. Association Between Metformin Use and the Risk, Prognosis of Gynecologic Cancer. - Kui Yao;Heng Zheng;Tao Li - Frontiers in oncology (2022)
  9. Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer. - Xiaolin Lang;Changchang Huang;Hongyin Cui - Journal of immunology research (2022)
  10. Long-term human papillomavirus vaccination effectiveness and immunity in Rwandan women living with and without HIV: a study protocol. - Gad Murenzi;Fabienne Shumbusho;Natasha Hansen;Athanase Munyaneza;Julia C Gage;Benjamin Muhoza;Faustin Kanyabwisha;Amanda Pierz;Patrick Tuyisenge;Kathryn Anastos;Philip E Castle - BMJ open (2022)

... (82 更多 篇文献)

© 2025 MaltSci 麦伴科研 - 我们用人工智能技术重塑科研