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Population bottlenecks and founder effects: implications for mosquito-borne arboviral emergence. ​

文献信息 ​

DOI10.1038/s41579-020-00482-8
PMID33432235
期刊Nature reviews. Microbiology
影响因子103.3
JCR 分区Q1
发表年份2021
被引次数50
关键词种群瓶颈, 创始效应, 蚊媒病毒, 遗传漂变, 人类疾病
文献类型Journal Article, Research Support, N.I.H., Extramural, Review
ISSN1740-1526
页码184-195
期号19(3)
作者Scott C Weaver, Naomi L Forrester, Jianying Liu, Nikos Vasilakis

一句话小结 ​

本综述探讨了节肢动物传播病毒（arboviruses）在宿主间传播过程中，因种群瓶颈和创始效应导致的遗传漂变对其进化及人类疾病出现的影响。研究表明，尽管存在适应性损失的风险，这些病毒仍能有效适应环境变化，对流行病和地方性循环产生重要影响。

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种群瓶颈 · 创始效应 · 蚊媒病毒 · 遗传漂变 · 人类疾病

摘要 ​

节肢动物传播病毒（arboviruses）的传播涉及到在节肢动物宿主和脊椎动物宿主中的感染与复制。几乎所有的arboviruses都是RNA病毒，具有高突变频率，这使它们在节肢动物感染、从中肠传播到唾液腺以及传递给脊椎动物宿主的过程中，容易受到遗传漂变和由于种群瓶颈而导致的适应性损失。然而，尽管存在这些瓶颈，它们似乎能够避免因穆勒的棘轮效应而导致的适应性下降。此外，在人类增强的arboviruses（如基孔肯雅病毒和寨卡病毒）地理引入过程中发生的创始效应，可能会影响流行病和地方性循环以及致病性。在本综述中，我们讨论了在种群瓶颈和创始效应之后遗传漂变在arboviral进化与传播以及人类疾病出现中的作用。

英文摘要 ​

Transmission of arthropod-borne viruses (arboviruses) involves infection and replication in both arthropod vectors and vertebrate hosts. Nearly all arboviruses are RNA viruses with high mutation frequencies, which leaves them vulnerable to genetic drift and fitness losses owing to population bottlenecks during vector infection, dissemination from the midgut to the salivary glands and transmission to the vertebrate host. However, despite these bottlenecks, they seem to avoid fitness declines that can result from Muller's ratchet. In addition, founder effects that occur during the geographic introductions of human-amplified arboviruses, including chikungunya virus and Zika virus, can affect epidemic and endemic circulation, as well as virulence. In this Review, we discuss the role of genetic drift following population bottlenecks and founder effects in arboviral evolution and spread, and the emergence of human disease.

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主要研究问题 ​

  1. 如何评估不同种类的蚊子在经历人口瓶颈后对病毒传播能力的影响？
  2. 在地理引入过程中，创始效应如何影响不同病毒株的传播速度和感染率？
  3. 有哪些因素可能导致蚊子传播的RNA病毒在经历瓶颈后避免适应性下降？
  4. 除了人类放大效应外，还有哪些生态因素可能影响蚊媒病毒的流行和变异？
  5. 如何利用对人口瓶颈和创始效应的理解来预测未来蚊媒病毒的疫情爆发？

核心洞察 ​

研究背景和目的 ​

本研究探讨了蚊子传播的虫媒病毒（arboviruses）在其传播过程中经历的种群瓶颈和创始效应对其进化和人类疾病传播的影响。尽管这些病毒具有高突变频率，但在面临种群瓶颈时，它们如何保持适应性及其潜在的适应机制仍然是一个重要的研究课题。

主要方法/材料/实验设计 ​

本研究通过文献综述的方式，分析了不同类型的虫媒病毒在传播过程中经历的瓶颈和创始效应。研究的重点在于病毒在以下几个关键步骤中遭遇的瓶颈：

  1. 蚊子中肠的感染：病毒通过感染蚊子的中肠开始传播。
  2. 进入血腔的扩散：病毒需要从中肠扩散到血腔。
  3. 唾液腺的感染：病毒必须感染蚊子的唾液腺以便传播给宿主。
  4. 向脊椎动物宿主的传播：通过蚊子的唾液将病毒传递给人类或其他脊椎动物。

以下是技术路线的流程图：

Mermaid diagram

关键结果和发现 ​

  • 种群瓶颈：病毒在传播过程中经历了多次种群瓶颈，导致遗传多样性减少和潜在的适应性下降。
  • 创始效应：新引入的病毒种群通常由少量病毒株建立，可能导致随机突变的固定，影响病毒的传播效率和致病性。
  • Muller’s ratchet现象：在缺乏有效重组的情况下，病毒可能会在反复的瓶颈中积累有害突变，导致适应性下降。

主要结论/意义/创新性 ​

本研究表明，尽管虫媒病毒在传播过程中面临显著的遗传瓶颈和创始效应，它们依然能够在自然界中保持相对稳定的基因组序列。研究强调了种群瓶颈和创始效应在病毒进化中的重要性，提示在病毒传播和疾病爆发预测中应考虑这些因素。

研究局限性和未来方向 ​

  • 局限性：本研究主要基于现有文献，缺乏实验数据支持具体机制的验证。
  • 未来方向：需要进一步的实验研究来探索病毒在不同宿主和环境条件下的适应机制，以及如何利用这些知识来预测和控制未来的病毒爆发。

总结而言，研究强调了对虫媒病毒的深入理解对于公共卫生和病毒控制策略的重要性。

参考文献 ​

  1. Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models. - Rose M Langsjoen;Sherry L Haller;Chad J Roy;Heather Vinet-Oliphant;Nicholas A Bergren;Jesse H Erasmus;Jill A Livengood;Tim D Powell;Scott C Weaver;Shannan L Rossi - mBio (2018)
  2. Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet. - E Duarte;D Clarke;A Moya;E Domingo;J Holland - Proceedings of the National Academy of Sciences of the United States of America (1992)
  3. Venezuelan equine encephalitis virus in the mosquito vector Aedes taeniorhynchus: infection initiated by a small number of susceptible epithelial cells and a population bottleneck. - Darci R Smith;A Paige Adams;Joan L Kenney;Eryu Wang;Scott C Weaver - Virology (2008)
  4. A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission. - Chao Shan;Hongjie Xia;Sherry L Haller;Sasha R Azar;Yang Liu;Jianying Liu;Antonio E Muruato;Rubing Chen;Shannan L Rossi;Maki Wakamiya;Nikos Vasilakis;Rongjuan Pei;Camila R Fontes-Garfias;Sanjay Kumar Singh;Xuping Xie;Scott C Weaver;Pei-Yong Shi - Proceedings of the National Academy of Sciences of the United States of America (2020)
  5. First Report of Aedes aegypti Transmission of Chikungunya Virus in the Americas. - Esteban E Díaz-González;Tiffany F Kautz;Alicia Dorantes-Delgado;Iliana R Malo-García;Maricela Laguna-Aguilar;Rose M Langsjoen;Rubing Chen;Dawn I Auguste;Rosa M Sánchez-Casas;Rogelio Danis-Lozano;Scott C Weaver;Ildefonso Fernández-Salas - The American journal of tropical medicine and hygiene (2015)
  6. Inter- and intra-host sequence diversity reveal the emergence of viral variants during an overwintering epidemic caused by dengue virus serotype 2 in southern Taiwan. - Hui-Ying Ko;Yao-Tsun Li;Day-Yu Chao;Yun-Cheng Chang;Zheng-Rong T Li;Melody Wang;Chuan-Liang Kao;Tzai-Hung Wen;Pei-Yun Shu;Gwong-Jen J Chang;Chwan-Chuen King - PLoS neglected tropical diseases (2018)
  7. Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. - K Lane Warmbrod;Edward I Patterson;Tiffany F Kautz;Adam Stanton;Dedeke Rockx-Brouwer;Birte K Kalveram;Kamil Khanipov;Saravanan Thangamani;Yuriy Fofanov;Naomi L Forrester - PLoS pathogens (2019)
  8. Spread of yellow fever virus outbreak in Angola and the Democratic Republic of the Congo 2015-16: a modelling study. - Moritz U G Kraemer;Nuno R Faria;Robert C Reiner;Nick Golding;Birgit Nikolay;Stephanie Stasse;Michael A Johansson;Henrik Salje;Ousmane Faye;G R William Wint;Matthias Niedrig;Freya M Shearer;Sarah C Hill;Robin N Thompson;Donal Bisanzio;Nuno Taveira;Heinrich H Nax;Bary S R Pradelski;Elaine O Nsoesie;Nicholas R Murphy;Isaac I Bogoch;Kamran Khan;John S Brownstein;Andrew J Tatem;Tulio de Oliveira;David L Smith;Amadou A Sall;Oliver G Pybus;Simon I Hay;Simon Cauchemez - The Lancet. Infectious diseases (2017)
  9. Chikungunya in the Americas. - Isabelle Leparc-Goffart;Antoine Nougairede;Sylvie Cassadou;Christine Prat;Xavier de Lamballerie - Lancet (London, England) (2014)
  10. Insect-Specific Viruses: A Historical Overview and Recent Developments. - Christopher M Roundy;Sasha R Azar;Shannan L Rossi;Scott C Weaver;Nikos Vasilakis - Advances in virus research (2017)

引用本文的文献 ​

  1. Current Status of Chikungunya in India. - - Frontiers in microbiology (2021)
  2. Multilocus Genotyping of 'Candidatus Phytoplasma solani' Associated with Rubbery Taproot Disease of Sugar Beet in the Pannonian Plain. - Živko Ćurčić;Andrea Kosovac;Jelena Stepanović;Emil Rekanović;Michael Kube;Bojan Duduk - Microorganisms (2021)
  3. Lineage Divergence and Vector-Specific Adaptation Have Driven Chikungunya Virus onto Multiple Adaptive Landscapes. - Rubing Chen;Jessica A Plante;Kenneth S Plante;Ruimei Yun;Divya Shinde;Jianying Liu;Sherry Haller;Suchetana Mukhopadhyay;Scott C Weaver - mBio (2021)
  4. Investigation of Biological Factors Contributing to Individual Variation in Viral Titer after Oral Infection of Aedes aegypti Mosquitoes by Sindbis Virus. - Peter Hodoameda;Linus Addae;Rollie J Clem - Viruses (2022)
  5. Glycosaminoglycan binding by arboviruses: a cautionary tale. - Maria D H Alcorn;William B Klimstra - The Journal of general virology (2022)
  6. Genetic Drift and Purifying Selection Shaped Mitochondrial Genome Variation in the High Royal Jelly-Producing Honeybee Strain (Apis mellifera ligustica). - Chuan Ma;Ruoyang Hu;Cecilia Costa;Jianke Li - Frontiers in genetics (2022)
  7. Impact of structural dynamics on biological functions of flaviviruses. - Karin Stiasny;Iris Medits;Lena Roßbacher;Franz X Heinz - The FEBS journal (2023)
  8. Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health-One Health Perspective. - Wojciech Socha;Malgorzata Kwasnik;Magdalena Larska;Jerzy Rola;Wojciech Rozek - Journal of clinical medicine (2022)
  9. Mitochondrial Genome Contributes to the Thermal Adaptation of the Oomycete Phytophthora infestans. - Lin-Lin Shen;Abdul Waheed;Yan-Ping Wang;Oswald Nkurikiyimfura;Zong-Hua Wang;Li-Na Yang;Jiasui Zhan - Frontiers in microbiology (2022)
  10. Heterogeneity of Rift Valley fever virus transmission potential across livestock hosts, quantified through a model-based analysis of host viral load and vector infection. - Hélène Cecilia;Roosmarie Vriens;Paul J Wichgers Schreur;Mariken M de Wit;Raphaëlle Métras;Pauline Ezanno;Quirine A Ten Bosch - PLoS computational biology (2022)

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