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Onconephrology: The intersections between the kidney and cancer.

文献信息

DOI10.3322/caac.21636
PMID32853404
期刊CA: a cancer journal for clinicians
影响因子232.4
JCR 分区Q1
发表年份2021
被引次数64
关键词急性肾损伤,化疗,慢性肾病,电解质,肾小球肾炎
文献类型Journal Article, Review
ISSN0007-9235
页码47-77
期号71(1)
作者Mitchell H Rosner, Kenar D Jhaveri, Blaithin A McMahon, Mark A Perazella

一句话小结

肿瘤肾脏病学作为肾脏病学的新分支,探讨了肾脏疾病与癌症之间的多重交集,发现肾脏疾病会显著影响癌症患者的预后和治疗效果,因此强调了肿瘤科与肾脏科医生的协作护理必要性。研究还推动了专门培训项目和门诊的发展,以提升对癌症患者肾脏问题的识别与管理。

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急性肾损伤 · 化疗 · 慢性肾病 · 电解质 · 肾小球肾炎

摘要

肿瘤肾脏病学是肾脏病学的一个新分支,旨在认识肾脏疾病与癌症之间的重要交集。这种交集表现形式多样,包括药物诱导的肾毒性、电解质紊乱、肿瘤性肾小球肾炎以及慢性肾脏疾病与癌症的相互作用。数据显示,当癌症患者出现急性或慢性肾脏疾病时,预后往往较差,治愈性治疗方案的效果也会受到影响。这强调了肿瘤科医生与肾脏科医生之间进行协作护理的必要性,以便及时识别和治疗癌症患者的肾脏疾病。针对这一需求,专门的肿瘤肾脏病学培训项目以及专门的肿瘤肾脏病学门诊相继出现。本文综合回顾了肿瘤肾脏病学中的许多关键主题,重点讨论急性肾损伤、慢性肾脏疾病、药物诱导的肾毒性、干细胞移植中的肾脏疾病以及癌症患者的电解质紊乱。

英文摘要

Onconephrology is a new subspecialty of nephrology that recognizes the important intersections of kidney disease with cancer. This intersection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, paraneoplastic glomerulonephritis, and the interactions of chronic kidney disease with cancer. Data clearly demonstrate that, when patients with cancer develop acute or chronic kidney disease, outcomes are inferior, and the promise of curative therapeutic regimens is lessened. This highlights the imperative for collaborative care between oncologists and nephrologists in recognizing and treating kidney disease in patients with cancer. In response to this need, specific training programs in onconephrology as well as dedicated onconephrology clinics have appeared. This comprehensive review covers many of the critical topics in onconephrology, with a focus on acute kidney injury, chronic kidney disease, drug-induced nephrotoxicity, kidney disease in stem cell transplantation, and electrolyte disorders in patients with cancer.

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主要研究问题

  1. 在肾脏疾病与癌症交叉领域中,如何评估药物诱导的肾毒性对癌症患者的长期影响?
  2. 对于慢性肾病患者,癌症的治疗策略应如何调整以降低肾脏并发症的风险?
  3. 在肾脏与癌症的交叉领域中,电解质失衡对患者的整体预后有什么具体影响?
  4. 在干细胞移植后,肾脏疾病的管理应如何与癌症治疗相结合,以优化患者的治疗结果?
  5. 针对癌症患者的特定肾脏疾病,现有的培训项目和专门诊所如何提高医务人员的诊治能力?

核心洞察

  1. 研究背景和目的
    肾脏病与癌症之间的关系日益受到关注,特别是在癌症患者中,肾脏疾病的发生频率显著增加。肾脏功能的下降不仅会影响癌症的治疗效果,还可能导致患者的预后不良。因此,建立肿瘤学与肾脏病学之间的协作关系显得尤为重要。本文旨在探讨肾脏病与癌症之间的相互影响,提出相应的临床管理策略,以及推动对肿瘤患者肾脏病的认识与治疗。

  2. 主要方法和发现
    该回顾性研究综合了多个关键主题,涵盖急性肾损伤、慢性肾病、药物诱导的肾毒性、干细胞移植中的肾脏疾病以及癌症患者的电解质失衡等方面。研究表明,癌症患者如发生急性或慢性肾病,其治疗效果和预后明显较差。数据分析显示,肾脏疾病的存在不仅影响治疗方案的选择,还降低了治愈的可能性。此外,随着对这一领域的认识加深,专门的培训项目和门诊逐渐建立,为患者提供更为细致的管理。

  3. 核心结论
    本研究强调,肾脏健康是癌症患者综合治疗的重要组成部分,肾脏病的存在对癌症患者的治疗和预后有着重要的影响。因此,肿瘤学家和肾脏病学家之间的紧密合作是提升患者整体治疗效果的关键。通过早期识别和干预肾脏疾病,可以显著改善癌症患者的治疗结果和生活质量。

  4. 研究意义和影响
    该研究为肿瘤患者的临床管理提供了新的视角,强调了肿瘤学与肾脏病学的交叉领域——肿瘤肾脏病学的重要性。通过建立专门的培训项目和门诊,能够提升医疗专业人士对肾脏疾病的认识,进而改善癌症患者的整体健康结果。这一新兴的学科将为未来的临床实践和研究提供重要指导,促进跨学科的合作与创新,最终提升患者的生存率和生活质量。

引用本文的文献

  1. The basics of onco-nephrology in the renal clinic. - Laura Cosmai;Camillo Porta;Marina Foramitti;Mimma Rizzo;Maurizio Gallieni - Journal of nephrology (2020)
  2. Renal Diseases Associated with Hematologic Malignancies and Thymoma in the Absence of Renal Monoclonal Immunoglobulin Deposits. - Antoine Morel;Marie-Sophie Meuleman;Anissa Moktefi;Vincent Audard - Diagnostics (Basel, Switzerland) (2021)
  3. Renal Complications Related to Checkpoint Inhibitors: Diagnostic and Therapeutic Strategies. - Julie Belliere;Julien Mazieres;Nicolas Meyer;Leila Chebane;Fabien Despas - Diagnostics (Basel, Switzerland) (2021)
  4. Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition. - Yuntao Bai;Ji Young Kim;Bijay Bisunke;Laura A Jayne;Josie A Silvaroli;Michael S Balzer;Megha Gandhi;Kevin M Huang;Veronika Sander;Jason Prosek;Rachel E Cianciolo;Sharyn D Baker;Alex Sparreboom;Kenar D Jhaveri;Katalin Susztak;Amandeep Bajwa;Navjot Singh Pabla - Kidney international (2021)
  5. The Crystalline Nephropathies. - Mark A Perazella;Leal C Herlitz - Kidney international reports (2021)
  6. Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging. - Ravneet Singh;Victoria L Nasci;Ginger Guthrie;Lale A Ertuglu;Maryam K Butt;Annet Kirabo;Eman Y Gohar - Biomolecules (2022)
  7. Utility of semi-private messaging application (WhatsApp®) for Onconephrology education: a qualitative analysis of a 'mastermind' chat. - Simoni Khashu;Nitya Wanchoo;Kayla D Finuf;Sebastian Lapman;Prakash Gudsoorkar;Kenar D Jhaveri - Clinical kidney journal (2022)
  8. Association between chronic kidney disease and cancer including the mortality of cancer patients: national health and nutrition examination survey 1999-2014. - Kanglin Guo;Zufeng Wang;Ran Luo;Yichun Cheng;Shuwang Ge;Gang Xu - American journal of translational research (2022)
  9. Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank. - Xianwen Shang;Xueli Zhang;Yu Huang;Zhuoting Zhu;Xiayin Zhang;Shunming Liu;Jiahao Liu;Shulin Tang;Wei Wang;Honghua Yu;Zongyuan Ge;Mingguang He - BMC medicine (2022)
  10. Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study. - Mónica Bolufer;Clara García-Carro;Miquel Blasco;Luis F Quintana;Amir Shabaka;Cristina Rabasco;Juliana Draibe;Ana Merino;María Rosa Melero;Fabiola Alonso;Anna Buxeda;Paula Batalha;Maria Teresa Visús;Maria José Soler - Journal of clinical medicine (2022)

... (54 更多 篇文献)


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