MaltSci 麦伴科研

Appearance

文献精选 > 高引权威"阿尔茨海默病"文献

Heavy Metals Exposure and Alzheimer's Disease and Related Dementias. ​

文献信息 ​

DOI10.3233/JAD-200282
PMID32651318
期刊Journal of Alzheimer's disease : JAD
影响因子3.1
JCR 分区Q2
发表年份2020
被引次数114
关键词镉, 流行病学, 重金属, 铅, 锰
文献类型Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
ISSN1387-2877
页码1215-1242
期号76(4)
作者Kelly M Bakulski, Young Ah Seo, Ruby C Hickman, Daniel Brandt, Harita S Vadari, Howard Hu, Sung Kyun Park

一句话小结 ​

本文回顾了铅、镉和锰等重金属与阿尔茨海默病及相关痴呆症之间的关联，指出这些金属的环境暴露可能显著增加认知功能受损的风险，尽管目前缺乏专门的纵向研究以确认其影响。研究强调了亟需开展高质量的流行病学研究，以评估这些重金属对阿尔茨海默病发病率的具体影响，从而应对这一重大公共卫生挑战。

在麦伴科研 (maltsci.com) 搜索更多文献 ​

镉 · 流行病学 · 重金属 · 铅 · 锰

摘要 ​

阿尔茨海默病及相关痴呆症缺乏有效的治疗或治愈方案，是重大公共卫生挑战。阿尔茨海默病及相关痴呆症的风险部分归因于环境因素。重金属铅、镉和锰在我们的环境中广泛存在且持久。一旦人们接触到这些金属，它们便能迅速进入细胞并到达大脑。即使在低剂量暴露的情况下，铅和镉与多种健康结果相关联。尽管锰是一种必需金属，但缺乏、环境暴露或高浓度的锰也可能具有毒性。在细胞和动物模型系统中，铅、镉和锰被充分证明是神经毒素，促进了经典的阿尔茨海默病病理。成人的人类流行病学研究一致表明，铅、镉和锰与认知功能受损和认知能力下降相关。然而，目前尚无纵向人类流行病学研究专门评估铅或锰暴露对阿尔茨海默病的影响，尽管已有两项研究报告了镉与阿尔茨海默病死亡率之间的关联。亟需更多具有高质量时间暴露数据和阿尔茨海默病及相关痴呆症新发病例的纵向流行病学研究，以确认并估计这些暴露所带来的风险比例。考虑到铅、镉和锰的广泛和全球性暴露，即使是阿尔茨海默病及相关痴呆症风险的微小增加，也会对疾病负担产生重大影响。本文回顾了铅、镉和锰与阿尔茨海默病及相关痴呆症之间关联的实验和流行病学文献，并提出了未来投资的关键领域建议。

英文摘要 ​

Alzheimer's disease and related dementias lack effective treatment or cures and are major public health challenges. Risk for Alzheimer's disease and related dementias is partially attributable to environmental factors. The heavy metals lead, cadmium, and manganese are widespread and persistent in our environments. Once persons are exposed to these metals, they are adept at entering cells and reaching the brain. Lead and cadmium are associated with numerous health outcomes even at low levels of exposure. Although manganese is an essential metal, deficiency or environmental exposure or high levels of the metal can be toxic. In cell and animal model systems, lead, cadmium, and manganese are well documented neurotoxicants that contribute to canonical Alzheimer's disease pathologies. Adult human epidemiologic studies have consistently shown lead, cadmium, and manganese are associated with impaired cognitive function and cognitive decline. No longitudinal human epidemiology study has assessed lead or manganese exposure on Alzheimer's disease specifically though two studies have reported a link between cadmium and Alzheimer's disease mortality. More longitudinal epidemiologic studies with high-quality time course exposure data and incident cases of Alzheimer's disease and related dementias are warranted to confirm and estimate the proportion of risk attributable to these exposures. Given the widespread and global exposure to lead, cadmium, and manganese, even small increases in the risks of Alzheimer's disease and related dementias would have a major population impact on the burden on disease. This article reviews the experimental and epidemiologic literature of the associations between lead, cadmium, and manganese on Alzheimer's disease and related dementias and makes recommendations of critical areas of future investment.

麦伴智能科研服务 ​

智能阅读回答你对文献的任何问题，帮助理解文献中的复杂图表和公式
定位观点定位某个观点在文献中的蛛丝马迹
加入知识库完成数据提取，报告撰写等更多高级知识挖掘功能

主要研究问题 ​

  1. 重金属暴露对阿尔茨海默病的具体影响机制是什么？
  2. 除了铅、镉和锰，还有哪些重金属可能与阿尔茨海默病相关？
  3. 在不同年龄段中，重金属暴露对认知功能的影响是否存在差异？
  4. 有哪些预防措施可以减少重金属暴露，从而降低阿尔茨海默病的风险？
  5. 目前针对重金属暴露与阿尔茨海默病关系的研究有哪些主要的争议和挑战？

核心洞察 ​

研究背景和目的 ​

阿尔茨海默病及相关痴呆症缺乏有效的治疗方法或治愈手段，是重大的公共卫生挑战。研究表明，阿尔茨海默病的风险部分源于环境因素，其中重金属铅、镉和锰在环境中广泛存在且持久。本文旨在回顾铅、镉和锰与阿尔茨海默病及相关痴呆症之间的关系，并提出未来研究的建议。

主要方法/材料/实验设计 ​

本文采用文献综述的方法，整合了实验室研究和流行病学研究的结果，探讨重金属对阿尔茨海默病的影响。具体方法包括：

  • 收集并分析细胞和动物模型中重金属的神经毒性证据。
  • 审查成人流行病学研究，评估铅、镉和锰与认知功能损害及认知衰退的关系。

以下是研究的技术路线图：

Mermaid diagram

关键结果和发现 ​

  • 重金属铅、镉和锰在细胞和动物模型中被广泛证实为神经毒性物质，能够促进阿尔茨海默病的典型病理特征。
  • 成人流行病学研究显示，铅、镉和锰与认知功能受损及认知衰退存在一致关联。
  • 尽管已有研究报告镉与阿尔茨海默病死亡率之间的联系，但尚无针对铅或锰的纵向研究明确其对阿尔茨海默病的影响。

主要结论/意义/创新性 ​

  • 小幅度的重金属暴露增加可能对阿尔茨海默病及相关痴呆症的风险产生显著影响，进而对公共卫生造成重大负担。
  • 该文献综述为理解环境因素如何影响阿尔茨海默病提供了重要视角，并强调了开展更高质量的纵向流行病学研究的必要性。

研究局限性和未来方向 ​

  • 目前缺乏针对铅和锰的纵向人类流行病学研究，亟需开展相关研究以确认和评估这些暴露所占风险的比例。
  • 未来研究应聚焦于：
    • 提供高质量的时间序列暴露数据。
    • 识别与阿尔茨海默病相关的环境风险因素。
    • 研究不同人群对重金属的敏感性，以制定更有效的公共卫生政策。

参考文献 ​

  1. Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. - Zhaobao Yin;Haiyan Jiang;Eun-Sook Y Lee;Mingwei Ni;Keith M Erikson;Dejan Milatovic;Aaron B Bowman;Michael Aschner - Journal of neurochemistry (2010)
  2. Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. - W Zheng - Microscopy research and technique (2001)
  3. Manganese Toxicity Upon Overexposure: a Decade in Review. - Stefanie L O'Neal;Wei Zheng - Current environmental health reports (2015)
  4. Neurotoxic effects and biomarkers of lead exposure: a review. - Talia Sanders;Yiming Liu;Virginia Buchner;Paul B Tchounwou - Reviews on environmental health (2009)
  5. The effects of early life Pb exposure on the expression of IL1-β, TNF-α and Aβ in cerebral cortex of mouse pups. - Ning Li;FangLi Liu;LianJun Song;PingAn Zhang;MingWu Qiao;QiuYan Zhao;WenJie Li - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2014)
  6. Cadmium concentration in blood in an elderly urban population. - M Nordberg;B Winblad;H Basun - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2000)
  7. Lead toxicity update. A brief review. - Nikolas C Papanikolaou;Eleftheria G Hatzidaki;Stamatis Belivanis;George N Tzanakakis;Aristidis M Tsatsakis - Medical science monitor : international medical journal of experimental and clinical research (2005)
  8. Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway. - Ruijie Zhang;Yu Zhu;Xiaoqing Dong;Beibei Liu;Nana Zhang;Xiaoxue Wang;Lei Liu;Chong Xu;Shile Huang;Long Chen - Journal of cellular physiology (2017)
  9. Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. - R L Hamilton - Brain pathology (Zurich, Switzerland) (2000)
  10. Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. - D Mergler;M Baldwin;S Bélanger;F Larribe;A Beuter;R Bowler;M Panisset;R Edwards;A de Geoffroy;M P Sassine;K Hudnell - Neurotoxicology (1999)

引用本文的文献 ​

  1. Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis. - Pablo Scharf;Milena Fronza Broering;Gustavo Henrique Oliveira da Rocha;Sandra Helena Poliselli Farsky - International journal of molecular sciences (2020)
  2. Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer's Disease. - Cosmin Stefan Mocanu;Monica Jureschi;Gabi Drochioiu - Molecules (Basel, Switzerland) (2020)
  3. (Ascorb)ing Pb Neurotoxicity in the Developing Brain. - Faraz Ahmad;Ping Liu - Antioxidants (Basel, Switzerland) (2020)
  4. Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity. - Daniela Ramírez Ortega;Dinora F González Esquivel;Tonali Blanco Ayala;Benjamín Pineda;Saul Gómez Manzo;Jaime Marcial Quino;Paul Carrillo Mora;Verónica Pérez de la Cruz - Toxics (2021)
  5. Direct and Indirect Neurotoxic Potential of Metal/Metalloids in Plants and Fungi Used for Food, Dietary Supplements, and Herbal Medicine. - Peter S Spencer;Valerie S Palmer - Toxics (2021)
  6. The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis. - Shannon Morgan McCabe;Ningning Zhao - Nutrients (2021)
  7. Bioaccumulation of Toxic Metals in Children Exposed to Urban Pollution and to Cement Plant Emissions. - Agostino Di Ciaula - Exposure and health (2021)
  8. Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors. - Faizan Ur Rahman;Maryam Bibi;Ezzat Khan;Abdul Bari Shah;Mian Muhammad;Muhammad Nawaz Tahir;Adnan Shahzad;Farhat Ullah;Muhammad Zahoor;Salman Alamery;Gaber El-Saber Batiha - Molecules (Basel, Switzerland) (2021)
  9. Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system. - Omamuyovwi M Ijomone;Joy D Iroegbu;Michael Aschner;Julia Bornhorst - Neurotoxicology (2021)
  10. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. - Md Ataur Rahman;Md Abdul Hannan;Md Jamal Uddin;Md Saidur Rahman;Md Mamunur Rashid;Bonglee Kim - Toxics (2021)

... (104 更多 篇文献)

© 2025 MaltSci 麦伴科研 - 我们用人工智能技术重塑科研