MaltSci 麦伴科研

Appearance

文献精选 > 近年高分"mRNA疫苗"研究（IF≥30，近5年）

Human papillomavirus vaccination 2020 guideline update: American Cancer Society guideline adaptation. ​

文献信息 ​

DOI10.3322/caac.21616
PMID32639044
期刊CA: a cancer journal for clinicians
影响因子232.4
JCR 分区Q1
发表年份2020
被引次数76
关键词癌症预防，人乳头瘤病毒（HPV），免疫接种，疫苗
文献类型Journal Article, Practice Guideline
ISSN0007-9235
页码274-280
期号70(4)
作者Debbie Saslow, Kimberly S Andrews, Deana Manassaram-Baptiste, Robert A Smith, Elizabeth T H Fontham

一句话小结 ​

美国癌症学会（ACS）调整了人乳头状瘤病毒（HPV）疫苗接种建议，强调在9至12岁间进行常规接种以提高按时接种率，推荐对26岁以下未充分接种者进行补种，而不支持对26岁以上成年人进行补种，因其效果有限。此调整旨在最大化疫苗预防癌症的潜力，并减轻临床决策负担。

在麦伴科研 (maltsci.com) 搜索更多文献 ​

癌症预防 · 人乳头瘤病毒（HPV） · 免疫接种 · 疫苗

摘要 ​

美国癌症学会（ACS）发布了对当前免疫接种实践咨询委员会关于人乳头状瘤病毒（HPV）疫苗接种建议的调整。ACS建议在9至12岁之间进行常规HPV疫苗接种，以实现更高的按时接种率，从而增加预防癌症的人数。建议医疗服务提供者在9岁或10岁时开始提供HPV疫苗系列接种。对于所有未充分接种的26岁以下人群，推荐进行补种HPV疫苗接种。医疗服务提供者应告知22至26岁之间尚未接种或未完成接种系列的个体，在年纪较大时接种疫苗在降低癌症风险方面的效果较差。并不推荐对26岁以上的成年人进行补种HPV疫苗接种。ACS不支持2019年免疫接种实践咨询委员会针对某些未充分接种的27至45岁成年人的共享临床决策建议，因为在这一年龄组中，疫苗接种的效果较低且癌症预防潜力有限，同时给患者和临床医生带来了决策负担，并且缺乏足够的指导来选择可能受益的个体。

英文摘要 ​

The American Cancer Society (ACS) presents an adaptation of the current Advisory Committee on Immunization Practices recommendations for human papillomavirus (HPV) vaccination. The ACS recommends routine HPV vaccination between ages 9 and 12 years to achieve higher on-time vaccination rates, which will lead to increased numbers of cancers prevented. Health care providers are encouraged to start offering the HPV vaccine series at age 9 or 10 years. Catch-up HPV vaccination is recommended for all persons through age 26 years who are not adequately vaccinated. Providers should inform individuals aged 22 to 26 years who have not been previously vaccinated or who have not completed the series that vaccination at older ages is less effective in lowering cancer risk. Catch-up HPV vaccination is not recommended for adults aged older than 26 years. The ACS does not endorse the 2019 Advisory Committee on Immunization Practices recommendation for shared clinical decision making for some adults aged 27 through 45 years who are not adequately vaccinated because of the low effectiveness and low cancer prevention potential of vaccination in this age group, the burden of decision making on patients and clinicians, and the lack of sufficient guidance on the selection of individuals who might benefit.

麦伴智能科研服务 ​

智能阅读回答你对文献的任何问题，帮助理解文献中的复杂图表和公式
定位观点定位某个观点在文献中的蛛丝马迹
加入知识库完成数据提取，报告撰写等更多高级知识挖掘功能

主要研究问题 ​

  1. 如何提高9至12岁儿童的HPV疫苗接种率以减少癌症发生率？
  2. 对于22至26岁未接种HPV疫苗的人群，如何有效传达疫苗接种的益处和重要性？
  3. 针对27至45岁成人的HPV疫苗接种，是否有其他有效的预防措施可以替代？
  4. 在实施HPV疫苗接种的过程中，医疗提供者面临哪些主要挑战和障碍？
  5. 有哪些国家或地区的HPV疫苗接种策略可以作为美国的借鉴，以提高接种率？

核心洞察 ​

1. 研究背景和目的 ​

人乳头瘤病毒（HPV）是引发多种癌症的重要病因，尤其是宫颈癌。为了降低HPV相关癌症的发生率，美国癌症协会（ACS）对现行的疫苗接种指南进行了适应性更新。该研究的目的是通过更新疫苗接种建议，促进更广泛的HPV疫苗接种，从而提高预防癌症的效果。

2. 主要方法和发现 ​

ACS根据美国免疫实践咨询委员会（ACIP）的建议，提出了适应性更新。推荐在9至12岁之间进行常规HPV疫苗接种，以提高按时接种率，从而增加预防癌症的数量。具体方法包括：

  • 建议医疗服务提供者在9或10岁时开始提供HPV疫苗系列；
  • 对于26岁以下未充分接种的人群，建议进行追补接种；
  • 对于22至26岁之间未接种或未完成疫苗系列的人，建议告知其在较大年龄接种的有效性较低；
  • 不推荐对26岁以上的成人进行追补接种。

此外，ACS未支持2019年ACIP对于27至45岁成人进行共享临床决策的建议，原因在于这一年龄段疫苗的有效性较低，癌症预防潜力有限，同时对患者和临床医生的决策负担较大。

3. 核心结论 ​

ACS更新的HPV疫苗接种指南强调了在儿童和青少年时期进行常规疫苗接种的重要性，认为越早接种越能有效预防HPV相关癌症。同时，针对26岁以上成人的追补接种不具备实际意义，尤其是在27至45岁之间的成年人，疫苗的效益不足以支持临床决策的复杂性。

4. 研究意义和影响 ​

本研究的更新为医疗服务提供者提供了清晰的疫苗接种指南，有助于提高HPV疫苗的接种率，进而有效降低HPV相关癌症的发病率。这些更新不仅可以改善公共卫生政策，还能帮助医生在临床实践中做出更好的决策，减轻患者的决策负担。通过促进早期接种，ACS的指导有望为未来的癌症预防工作提供坚实基础，推动健康教育和疫苗接种的广泛普及。

引用本文的文献 ​

  1. Screening for Cervical Cancer. - Terresa J Eun;Rebecca B Perkins - The Medical clinics of North America (2020)
  2. Assessing the Long-Term Role of Vaccination against HPV after Loop Electrosurgical Excision Procedure (LEEP): A Propensity-Score Matched Comparison. - Giorgio Bogani;Francesco Raspagliesi;Francesco Sopracordevole;Andrea Ciavattini;Alessandro Ghelardi;Tommaso Simoncini;Marco Petrillo;Francesco Plotti;Salvatore Lopez;Jvan Casarin;Maurizio Serati;Ciro Pinelli;Gaetano Valenti;Alice Bergamini;Barbara Gardella;Andrea Dell'Acqua;Ermelinda Monti;Paolo Vercellini;Giovanni D'ippolito;Lorenzo Aguzzoli;Vincenzo D Mandato;Paola Carunchio;Gabriele Carlifante;Luca Gianella;Cono Scaffa;Francesca Falcone;Stefano Ferla;Chiara Borghi;Antonino Ditto;Mario Malzoni;Andrea Giannini;Maria Giovanna Salerno;Viola Liberale;Biagio Contino;Cristina Donfrancesco;Michele Desiato;Anna Myriam Perrone;Giulia Dondi;Pierandrea De Iaco;Umberto Leone Roberti Maggiore;Mauro Signorelli;Valentina Chiappa;Simone Ferrero;Giuseppe Sarpietro;Maria G Matarazzo;Antonio Cianci;Sara Bocio;Simona Ruisi;Rocco Guerrisi;Claudia Brusadelli;Lavinia Mosca;Raffaele Tinelli;Rosa De Vincenzo;Gian Franco Zannoni;Gabriella Ferrandina;Salvatore Dessole;Roberto Angioli;Stefano Greggi;Arsenio Spinillo;Fabio Ghezzi;Nicola Colacurci;Margherita Fischetti;Annunziata Carlea;Fulvio Zullo;Ludovico Muzii;Giovanni Scambia;Pierluigi Benedetti Panici;Violante Di Donato - Vaccines (2020)
  3. Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For. - Michele Carbone;John Lednicky;Shu-Yuan Xiao;Mario Venditti;Enrico Bucci - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2021)
  4. A National Survey of Obstetrician/Gynecologists' Knowledge, Attitudes, and Beliefs Regarding Adult Human Papillomavirus Vaccination. - Monica L Kasting;Katharine J Head;Andrea L DeMaria;Monica K Neuman;Allissa L Russell;Sharon E Robertson;Caroline E Rouse;Gregory D Zimet - Journal of women's health (2002) (2021)
  5. Including vaccinations in the scope of dental practice: The time has come. - Alessandro Villa;Milda Chmieliauskaite;Lauren L Patton - Journal of the American Dental Association (1939) (2021)
  6. Nanomaterials for Protein Delivery in Anticancer Applications. - Anne Yau;Jinhyung Lee;Yupeng Chen - Pharmaceutics (2021)
  7. In the Name of Prevention: Maternal Perspectives on School-Based HPV Vaccination in Rural Southern Chile. - Ryan Arams;Rachel E Weinstock;Emma Satterthwaite Muresianu;Stasha O'Callaghan;Elizabeth Tubridy;Yumarlin Torres Maita;Siobhan M Dolan - Adolescent health, medicine and therapeutics (2021)
  8. Human Papilloma Virus Vaccination. - Kendal Rosalik;Christopher Tarney;Jasmine Han - Viruses (2021)
  9. Gaps and Opportunities to Improve Prevention of Human Papillomavirus-Related Cancers. - Irene O Aninye;J Michael Berry-Lawhorn;Paul Blumenthal;Tamika Felder;Naomi Jay;Janette Merrill;Jenna B Messman;Sarah Nielsen;Rebecca Perkins;Tami Rowen;Debbie Saslow;Connie Liu Trimble;Karen Smith-McCune - Journal of women's health (2002) (2021)
  10. Vaccination against Cancer or Infectious Agents during Checkpoint Inhibitor Therapy. - Tahseen H Nasti;Christiane S Eberhardt - Vaccines (2021)

... (66 更多 篇文献)

© 2025 MaltSci 麦伴科研 - 我们用人工智能技术重塑科研