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文献精选 > 高引权威"肿瘤微环境"文献

Tumor Microenvironment. ​

文献信息 ​

DOI10.3390/medicina56010015
PMID31906017
期刊Medicina (Kaunas, Lithuania)
影响因子2.4
JCR 分区Q1
发表年份2019
被引次数745
关键词癌症, 癌症微环境, 肿瘤, 肿瘤生长, 肿瘤微环境
文献类型Journal Article, Review
ISSN1010-660X
期号56(1)
作者Borros Arneth

一句话小结 ​

本研究回顾了肿瘤微环境在癌症发生与发展的重要性，指出非恶性细胞如脂肪细胞、成纤维细胞等在肿瘤进展中发挥关键作用。研究强调，针对肿瘤微环境中的细胞和分子进行干预，有望改善癌症治疗效果并促进积极的健康结果。

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癌症 · 癌症微环境 · 肿瘤 · 肿瘤生长 · 肿瘤微环境

摘要 ​

背景与目标
肿瘤微环境在肿瘤发生中广泛被认为具有重要作用，因为它包含肿瘤细胞，这些细胞通过循环系统和淋巴系统与周围细胞相互作用，从而影响癌症的发生和发展。此外，肿瘤微环境中的非恶性细胞在癌变的各个阶段发挥着关键作用，通过刺激和促进细胞的失控增殖。

目标
本研究旨在通过对相关主题先前研究的批判性回顾，探讨肿瘤微环境的概念。材料与方法：本次回顾依赖于先前研究中提供的证据。所包含的文章均来自不同的医学和健康数据库。

结果与讨论
肿瘤微环境在癌症文献中受到了显著关注，特别是其在肿瘤发展和进展中的作用。先前的研究已识别出影响恶性行为和进展的肿瘤微环境的各种成分。除了恶性细胞外，肿瘤微环境中还存在脂肪细胞、成纤维细胞、肿瘤血管、淋巴细胞、树突状细胞和癌症相关成纤维细胞。这些细胞类型各自具有独特的免疫能力，决定了肿瘤是否能够存活并影响邻近细胞。

结论
肿瘤微环境中存在癌症干细胞和其他分子，这些分子促进肿瘤的发展和进展。因此，在癌症治疗过程中，针对和操控肿瘤微环境中的细胞和因素，有助于控制恶性肿瘤并实现积极的健康结果。

英文摘要 ​

BACKGROUND AND OBJECTIVES The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in all the stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation.

AIM This study aims to explore the concept of the tumor microenvironment by conducting a critical review of previous studies on the topic. Materials and Methods: This review relies on evidence presented in previous studies related to the topic. The articles included in this review were obtained from different medical and health databases.

RESULTS AND DISCUSSION The tumor microenvironment has received significant attention in the cancer literature, with a particular focus on its role in tumor development and progression. Previous studies have identified various components of the tumor microenvironment that influence malignant behavior and progression. In addition to malignant cells, adipocytes, fibroblasts, tumor vasculature, lymphocytes, dendritic cells, and cancer-associated fibroblasts are present in the tumor microenvironment. Each of these cell types has unique immunological capabilities that determine whether the tumor will survive and affect neighboring cells.

CONCLUSION The tumor microenvironment harbors cancer stem cells and other molecules that contribute to tumor development and progression. Consequently, targeting and manipulating the cells and factors in the tumor microenvironment during cancer treatment can help control malignancies and achieve positive health outcomes.

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主要研究问题 ​

  1. 肿瘤微环境中不同细胞类型的相互作用如何影响肿瘤的生长和转移？
  2. 在肿瘤微环境中，癌症相关成纤维细胞的功能与其他细胞类型相比有什么独特之处？
  3. 肿瘤微环境对免疫治疗的影响有哪些，如何利用这些信息改善治疗效果？
  4. 如何通过调节肿瘤微环境中的非肿瘤细胞来增强抗肿瘤疗法的有效性？
  5. 肿瘤微环境中脂肪细胞的作用是什么，它们如何影响肿瘤的代谢和进展？

核心洞察 ​

研究背景和目的 ​

肿瘤微环境（TME）在肿瘤发生中起着重要作用，它包含肿瘤细胞及其周围的非肿瘤细胞，通过循环和淋巴系统相互作用，影响癌症的发展和进展。非恶性细胞在癌变的各个阶段发挥关键作用，促进细胞的无控制增殖。本研究旨在通过对相关文献的批判性回顾，探讨肿瘤微环境的概念及其在癌症中的作用。

主要方法/材料/实验设计 ​

本研究基于对以往文献的回顾，分析了肿瘤微环境相关的研究结果。通过在PsycINFO、CINAHL、PubMed和Web of Science等数据库中检索“肿瘤微环境”、“癌症干细胞”、“肿瘤发生”等关键词，筛选出2008年至2017年间发表的英文文章，并对其摘要进行仔细审查，评估其质量和适用性。

Mermaid diagram

关键结果和发现 ​

  • TME的成分包括肿瘤细胞、脂肪细胞、成纤维细胞、肿瘤血管、淋巴细胞、树突状细胞和癌症相关成纤维细胞等。
  • 这些细胞在肿瘤的生长、转移和药物抵抗中发挥着不同的作用。
  • 研究表明，TME中的非肿瘤细胞通常促进肿瘤进展，且肿瘤细胞能够通过分泌信号分子来影响周围微环境。

主要结论/意义/创新性 ​

肿瘤微环境是肿瘤发生和发展的复杂生态系统，包含多种细胞和分子，能够增强肿瘤细胞的干性、促进血管生成、介导细胞迁移、诱导药物抵抗及抑制免疫反应。因此，针对TME的治疗策略可能成为控制癌症的重要手段。

研究局限性和未来方向 ​

尽管TME的组成和结构在不同癌症类型和患者中存在差异，但目前对其具体功能和动态变化的了解仍然有限。未来的研究应聚焦于如何有效地靶向TME中的细胞和分子，以改善癌症患者的治疗效果。同时，深入理解TME在肿瘤进展中的作用，将为新型抗癌疗法的开发提供基础。

研究内容关键发现
TME成分包含肿瘤细胞、成纤维细胞、免疫细胞等
细胞相互作用非肿瘤细胞在癌症发展中发挥促进作用
治疗前景针对TME的靶向治疗可能改善患者预后

通过对肿瘤微环境的深入研究，可以为癌症的管理和治疗提供新的思路和策略。

参考文献 ​

  1. The role of the tumor microenvironment in regulating angiogenesis. - Randolph S Watnick - Cold Spring Harbor perspectives in medicine (2012)
  2. Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth. - Kazuyoshi Shiga;Masayasu Hara;Takaya Nagasaki;Takafumi Sato;Hiroki Takahashi;Hiromitsu Takeyama - Cancers (2015)
  3. Treatment of advanced renal cell carcinoma patients with cabozantinib, an oral multityrosine kinase inhibitor of MET, AXL and VEGF receptors. - Arpita Desai;Eric J Small - Future oncology (London, England) (2019)
  4. Leukocyte trafficking in tumor microenvironment. - Annalisa Del Prete;Tiziana Schioppa;Laura Tiberio;Helena Stabile;Silvano Sozzani - Current opinion in pharmacology (2017)
  5. Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response. - Shamir Cassim;Jacques Pouyssegur - International journal of molecular sciences (2019)
  6. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. - Matthew Kraman;Paul J Bambrough;James N Arnold;Edward W Roberts;Lukasz Magiera;James O Jones;Aarthi Gopinathan;David A Tuveson;Douglas T Fearon - Science (New York, N.Y.) (2010)
  7. Biological effects of cancer-secreted factors on human mesenchymal stem cells. - Paula Y P Lam - Stem cell research & therapy (2013)
  8. Sustained lower rates of breast cancer in the United States. - Kathleen A Cronin;Peter M Ravdin;Brenda K Edwards - Breast cancer research and treatment (2009)
  9. Crosstalk between T lymphocytes and dendritic cells. - Claire Hivroz;Karine Chemin;Marie Tourret;Armelle Bohineust - Critical reviews in immunology (2012)
  10. The cellular and molecular origin of tumor-associated macrophages. - Ruth A Franklin;Will Liao;Abira Sarkar;Myoungjoo V Kim;Michael R Bivona;Kang Liu;Eric G Pamer;Ming O Li - Science (New York, N.Y.) (2014)

引用本文的文献 ​

  1. Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer. - Jacek Baj;Izabela Korona-Głowniak;Alicja Forma;Amr Maani;Elżbieta Sitarz;Mansur Rahnama-Hezavah;Elżbieta Radzikowska;Piero Portincasa - Cells (2020)
  2. Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications. - Neel Rajan;Tilak Khanal;Matthew D Ringel - Endocrine (2020)
  3. Role of Stromal Cells in Determining Tumor and Cancer Stem Cell Behaviors and Therapeutic Response. - Stephan J Reshkin;Rosa Angela Cardone - Cancers (2020)
  4. CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. - Jan Korbecki;Klaudyna Kojder;Donata Simińska;Romuald Bohatyrewicz;Izabela Gutowska;Dariusz Chlubek;Irena Baranowska-Bosiacka - International journal of molecular sciences (2020)
  5. Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-ras Transgenic Mice. - Shan-Ming Chen;Li-Jin Hsu;Hsiang-Lin Lee;Ching-Pin Lin;Szu-Wei Huang;Caucasus Jun-Lin Lai;Chia-Wei Lin;Wan-Ting Chen;Yu-Jen Chen;Yu-Chien Lin;Chi-Chieh Yang;Ming-Shiou Jan - Cancers (2020)
  6. The Tumor Microenvironment-A Metabolic Obstacle to NK Cells' Activity. - Joanna Domagala;Mieszko Lachota;Marta Klopotowska;Agnieszka Graczyk-Jarzynka;Antoni Domagala;Andriy Zhylko;Karolina Soroczynska;Magdalena Winiarska - Cancers (2020)
  7. A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults. - Chunkai Wen;Hongxue Wang;Han Wang;Hao Mo;Wuning Zhong;Jing Tang;Yongkui Lu;Wenxian Zhou;Aihua Tan;Yan Liu;Weimin Xie - Aging (2020)
  8. Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1. - Erica Buoso;Mirco Masi;Marco Racchi;Emanuela Corsini - International journal of molecular sciences (2020)
  9. Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy. - Changhua Mu;David E Korenchan;Sinan Wang;David M Wilson;Robert R Flavell - Molecular imaging and biology (2021)
  10. Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy. - Wen-Jun Zhang - Purinergic signalling (2021)

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