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文献精选 > 近年高分"阿尔茨海默病"研究（IF≥30，近5年）

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. ​

文献信息 ​

DOI10.3322/caac.21572
PMID31283845
期刊CA: a cancer journal for clinicians
影响因子232.4
JCR 分区Q1
发表年份2019
被引次数250
关键词BRCA1相关蛋白1（BAP1）、石棉、癌症综合征、染色体震荡、基因-环境相互作用
文献类型Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review
ISSN0007-9235
页码402-429
期号69(5)
作者Michele Carbone, Prasad S Adusumilli, H Richard Alexander, Paul Baas, Fabrizio Bardelli, Angela Bononi, Raphael Bueno, Emanuela Felley-Bosco, Francoise Galateau-Salle, David Jablons, Aaron S Mansfield, Michael Minaai, Marc de Perrot, Patricia Pesavento, Valerie Rusch, David T Severson, Emanuela Taioli, Anne Tsao, Gavitt Woodard, Haining Yang, Marjorie G Zauderer, Harvey I Pass

一句话小结 ​

间皮瘤主要影响接触石棉的老年人，但发展中国家缺乏相关数据，导致全球发病率和死亡率尚不明确。尽管发达国家因严格管控石棉而降低了发病率，但老年人口增加和环境中致癌纤维的扰动使得总死亡人数未见减少，强调了加强国际合作以改善预防和治疗的重要性。

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BRCA1相关蛋白1（BAP1） · 石棉 · 癌症综合征 · 染色体震荡 · 基因-环境相互作用

摘要 ​

间皮瘤主要影响那些职业上接触过石棉的老年人。全球间皮瘤的发病率和死亡率尚不明确，因为发展中国家的数据不可用，而这些国家仍在大量使用石棉。澳大利亚、美国和西欧的间皮瘤发病率在1970年代和1980年代禁止或严格管控石棉使用后有所下降，显示了这些预防措施的价值。然而，在这些国家，间皮瘤导致的总死亡人数并没有减少，因为人口规模和老年人比例在增加。此外，随着农村地区的开发，环境中存在的致癌纤维被扰动，可能会形成间皮瘤的热点。新型免疫组化和分子标志物提高了诊断的准确性；然而，在高资源国家中约有14%至50%（发展中国家）的间皮瘤诊断是错误的，导致治疗不当，并使流行病学研究更加复杂。发现生殖系BRCA1相关蛋白1（BAP1）突变会导致间皮瘤和其他癌症（BAP1癌症综合征），阐明了一些关键的致病机制，目前针对这些分子机制和/或调节免疫反应的治疗正在进行试验。关于胸膜间皮瘤的手术角色存在争议，因为即使在现有或新型全身治疗中加入局部治疗，也很难预测谁将从积极治疗中受益。然而，对于腹膜间皮瘤的治疗结果正在改善。加强国际多学科合作将是改善预防、早期发现和治疗的必要条件。

英文摘要 ​

Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high-resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1-asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment.

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主要研究问题 ​

  1. 如何进一步提高对开发中国家中间皮瘤的早期诊断率？
  2. 在不同国家中，哪些特定的环境因素会导致中间皮瘤的发病率增加？
  3. 近年来在中间皮瘤治疗中，免疫疗法的研究进展如何，未来的方向是什么？
  4. 针对中间皮瘤的多学科合作研究中，哪些国家或地区的实践经验值得借鉴？
  5. BRCA1相关蛋白1（BAP1）突变的发现对中间皮瘤的遗传筛查有何影响？

核心洞察 ​

研究背景和目的 ​

间皮瘤是一种主要由石棉暴露引起的恶性肿瘤，主要影响老年人。尽管在某些国家（如澳大利亚、美国和西欧）由于严格的石棉使用限制，间皮瘤的发病率有所下降，但整体死亡人数并未显著减少。本文旨在总结间皮瘤的流行病学、发病机制、诊断方法、治疗策略及未来研究方向。

主要方法/材料/实验设计 ​

本研究通过文献回顾和数据分析的方法，综合了近年来关于间皮瘤的流行病学、分子生物学和临床研究的最新发现。

Mermaid diagram

关键结果和发现 ​

  1. 流行病学：间皮瘤的发病率在高收入国家有所下降，但在某些发展中国家仍在上升。石棉暴露是主要致病因素，且有证据表明环境暴露和遗传易感性也起到重要作用。
  2. 分子机制：发现BRCA1相关蛋白1（BAP1）突变与间皮瘤发生密切相关，BAP1突变不仅是遗传易感性因素，也是肿瘤发生的重要驱动因素。
  3. 诊断方法：新型免疫组化和分子标记物的应用提高了间皮瘤的诊断准确性，但仍有相当比例的误诊（高达50%）。
  4. 治疗策略：手术治疗的效果存在争议，尽管一些患者在多学科治疗中受益，但整体生存率提升有限。化疗和免疫治疗正在探索中。

主要结论/意义/创新性 ​

本研究强调了间皮瘤的多因素病因，特别是遗传因素在发病机制中的重要性。对BAP1的研究为靶向治疗提供了新的思路。此外，文中提出了加强早期诊断和提高治疗效果的建议。

研究局限性和未来方向 ​

  1. 局限性：研究依赖于现有文献，可能存在数据偏倚，且部分地区的流行病学数据缺乏。
  2. 未来方向：建议开展更多的国际合作研究，以促进早期预防、诊断和治疗策略的制定。此外，基因检测和靶向治疗的临床试验也应加强，以便为患者提供个性化治疗方案。

表格总结 ​

项目结果/发现
流行病学高收入国家发病率下降，发展中国家上升
分子机制BAP1突变与间皮瘤发生相关
诊断方法新型标记物提高诊断准确性，但误诊率高
治疗策略手术和化疗效果有限，免疫治疗有待探索
未来方向加强国际合作，推动基因检测与靶向治疗研究

参考文献 ​

  1. The role of perioperative systemic chemotherapy in diffuse malignant peritoneal mesothelioma patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. - Marcello Deraco;Dario Baratti;Ionut Hutanu;Rossella Bertuli;Shigeki Kusamura - Annals of surgical oncology (2013)
  2. Age and sex differences in malignant mesothelioma after residential exposure to blue asbestos (crocidolite). - Alison Reid;Geoffrey Berry;Nicholas de Klerk;Janice Hansen;Jane Heyworth;Gina Ambrosini;Lin Fritschi;Nola Olsen;Enzo Merler;A W Bill Musk - Chest (2007)
  3. In Situ Vaccination after Accelerated Hypofractionated Radiation and Surgery in a Mesothelioma Mouse Model. - Luis De La Maza;Matthew Wu;Licun Wu;Hana Yun;Yidan Zhao;Mark Cattral;Andrea McCart;Bc John Cho;Marc de Perrot - Clinical cancer research : an official journal of the American Association for Cancer Research (2017)
  4. Impact of mesothelioma histologic subtype on outcomes in the Surveillance, Epidemiology, and End Results database. - Robert Ryan Meyerhoff;Chi-Fu Jeffrey Yang;Paul J Speicher;Brian C Gulack;Matthew G Hartwig;Thomas A D'Amico;David H Harpole;Mark F Berry - The Journal of surgical research (2015)
  5. High incidence of lung cancer and malignant mesothelioma linked to erionite fibre exposure in a rural community in Central Mexico. - M Adrián Ortega-Guerrero;Gerardo Carrasco-Núñez;Héctor Barragán-Campos;Martín R Ortega - Occupational and environmental medicine (2015)
  6. Loss of the tumor suppressor BAP1 causes myeloid transformation. - Anwesha Dey;Dhaya Seshasayee;Rajkumar Noubade;Dorothy M French;Jinfeng Liu;Mira S Chaurushiya;Donald S Kirkpatrick;Victoria C Pham;Jennie R Lill;Corey E Bakalarski;Jiansheng Wu;Lilian Phu;Paula Katavolos;Lindsay M LaFave;Omar Abdel-Wahab;Zora Modrusan;Somasekar Seshagiri;Ken Dong;Zhonghua Lin;Mercedesz Balazs;Rowena Suriben;Kim Newton;Sarah Hymowitz;Guillermo Garcia-Manero;Flavius Martin;Ross L Levine;Vishva M Dixit - Science (New York, N.Y.) (2012)
  7. Loss of BAP1 function leads to EZH2-dependent transformation. - Lindsay M LaFave;Wendy Béguelin;Richard Koche;Matt Teater;Barbara Spitzer;Alan Chramiec;Efthymia Papalexi;Matthew D Keller;Todd Hricik;Katerina Konstantinoff;Jean-Baptiste Micol;Benjamin Durham;Sarah K Knutson;John E Campbell;Gil Blum;Xinxu Shi;Emma H Doud;Andrei V Krivtsov;Young Rock Chung;Inna Khodos;Elisa de Stanchina;Ouathek Ouerfelli;Prasad S Adusumilli;Paul M Thomas;Neil L Kelleher;Minkui Luo;Heike Keilhack;Omar Abdel-Wahab;Ari Melnick;Scott A Armstrong;Ross L Levine - Nature medicine (2015)
  8. Malignant Mesothelioma Mortality - United States, 1999-2015. - Jacek M Mazurek;Girija Syamlal;John M Wood;Scott A Hendricks;Ainsley Weston - MMWR. Morbidity and mortality weekly report (2017)
  9. Epidemiology of Environmental Exposure and Malignant Mesothelioma. - Bian Liu;Maaike van Gerwen;Stefano Bonassi;Emanuela Taioli; - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2017)
  10. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. - Michele Carbone;Laura Korb Ferris;Francine Baumann;Andrea Napolitano;Christopher A Lum;Erin G Flores;Giovanni Gaudino;Amy Powers;Peter Bryant-Greenwood;Thomas Krausz;Elizabeth Hyjek;Rachael Tate;Joseph Friedberg;Tracey Weigel;Harvey I Pass;Haining Yang - Journal of translational medicine (2012)

引用本文的文献 ​

  1. From "shift work that involves circadian disruption" to "night shift work". - Masaya Takahashi;Shigeki Koda - Industrial health (2019)
  2. Metabolic rewiring and redox alterations in malignant pleural mesothelioma. - Loredana Urso;Ilaria Cavallari;Evgeniya Sharova;Francesco Ciccarese;Giulia Pasello;Vincenzo Ciminale - British journal of cancer (2020)
  3. Mesothelioma Driver Genes, Ferroptosis, and Therapy. - Emanuela Felley-Bosco;Steven G Gray - Frontiers in oncology (2019)
  4. The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo. - Walter Blum;Thomas Henzi;László Pecze;Kim-Long Diep;Christian G Bochet;Beat Schwaller - Oncotarget (2019)
  5. Comments on Vimercati et al., 2019, "Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register". - Gabor Mezei;Ellen T Chang;Fionna S Mowat;Suresh H Moolgavkar - Environmental health : a global access science source (2019)
  6. Response to the "Letter to the Editor" by Gabor Mezei et al., Comments on Vimercati et al., 2019, "Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (Southern Italy) mesothelioma register". - Luigi Vimercati;Domenica Cavone;Maria Celeste Delfino;Luigi De Maria;Antonio Caputi;Giovanni Maria Ferri;Gabriella Serio - Environmental health : a global access science source (2019)
  7. Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas. - Robin Guo;Mariel DuBoff;Gowtham Jayakumaran;Mark G Kris;Marc Ladanyi;Mark E Robson;Diana Mandelker;Marjorie G Zauderer - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2020)
  8. Diffuse epithelioid malignant mesothelioma of the pleura presenting as a hydropneumothorax and vertebral body invasion. - Colin Andrew Hinkamp;Shanup N Dalal;Yasmeen Butt;Alberto V Cabo Chan - BMJ case reports (2020)
  9. Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression. - Daniel Rathkey;Manakamana Khanal;Junko Murai;Jingli Zhang;Manjistha Sengupta;Qun Jiang;Betsy Morrow;Christine N Evans;Raj Chari;Patricia Fetsch;Hye-Jung Chung;Liqiang Xi;Mark Roth;Armando Filie;Mark Raffeld;Anish Thomas;Yves Pommier;Raffit Hassan - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2020)
  10. Malignant Pleural Mesothelioma: State-of-the-Art on Current Therapies and Promises for the Future. - Fabio Nicolini;Martine Bocchini;Giuseppe Bronte;Angelo Delmonte;Massimo Guidoboni;Lucio Crinò;Massimiliano Mazza - Frontiers in oncology (2019)

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