MaltSci 麦伴科研

Appearance

文献精选 > 近年高分"阿尔茨海默病"研究（IF≥30，近5年）

Implications of sleep disturbance and inflammation for Alzheimer's disease dementia. ​

文献信息 ​

DOI10.1016/S1474-4422(18)30450-2
PMID30661858
期刊The Lancet. Neurology
影响因子45.5
JCR 分区Q1
发表年份2019
被引次数251
关键词睡眠障碍, 阿尔茨海默病, 炎症, β-淀粉样蛋白, 认知衰退
文献类型Journal Article, Research Support, N.I.H., Extramural, Review
ISSN1474-4422
页码296-306
期号18(3)
作者Michael R Irwin, Michael V Vitiello

一句话小结 ​

研究表明，超过60岁的成年人中约一半存在睡眠障碍，这些障碍可能通过增加β-淀粉样蛋白负担和引发系统性炎症，提高阿尔茨海默病的风险。理解睡眠障碍与阿尔茨海默病之间的关系，有助于识别可预防的靶点，从而为降低该疾病的风险提供新的思路。

在麦伴科研 (maltsci.com) 搜索更多文献 ​

睡眠障碍 · 阿尔茨海默病 · 炎症 · β-淀粉样蛋白 · 认知衰退

摘要 ​

超过60岁的成年人大约有一半报告存在睡眠障碍，这些障碍表现为失眠投诉及其白天后果、对睡眠质量或数量的不满，或被诊断为失眠症。越来越多的证据显示，睡眠障碍会导致认知能力下降，并可能通过增加β-淀粉样蛋白负担来提高阿尔茨海默病痴呆的风险。考虑到睡眠障碍通常被视为阿尔茨海默病的结果，认为睡眠障碍可能是阿尔茨海默病的潜在风险因素似乎令人惊讶。然而，睡眠与阿尔茨海默病之间的双向关系得到了我们对睡眠障碍引起的系统性炎症增加的理解的支持，这可以被视为阿尔茨海默病发展过程中早期的一个事件。炎症会增加β-淀粉样蛋白负担，并被认为是推动阿尔茨海默病发病机制的因素。更好地理解连接睡眠障碍与阿尔茨海默病风险之间机制的研究，可能有助于识别预防的靶点，因为睡眠障碍和炎症激活可能是可以改变的阿尔茨海默病风险因素。

英文摘要 ​

Nearly half of all adults older than 60 years of age report sleep disturbance, as characterised either by reports of insomnia complaints with daytime consequences, dissatisfaction with sleep quality or quantity, or the diagnosis of insomnia disorder. Accumulating evidence shows that sleep disturbance contributes to cognitive decline and might also increase the risk of Alzheimer's disease dementia by increasing β-amyloid burden. That sleep disturbance would be a candidate risk factor for Alzheimer's disease might seem surprising, given that disturbed sleep is usually considered a consequence of Alzheimer's disease. However, a bidirectional relationship between sleep and Alzheimer's disease is supported by advances in our understanding of sleep disturbance-induced increases in systemic inflammation, which can be viewed as an early event in the course of Alzheimer's disease. Inflammation increases β-amyloid burden and is thought to drive Alzheimer's disease pathogenesis. Improved understanding of the mechanisms linking sleep disturbance and Alzheimer's disease risk could facilitate the identification of targets for prevention, given that both sleep disturbance and inflammatory activation might be modifiable risk factors for Alzheimer's disease.

麦伴智能科研服务 ​

智能阅读回答你对文献的任何问题，帮助理解文献中的复杂图表和公式
定位观点定位某个观点在文献中的蛛丝马迹
加入知识库完成数据提取，报告撰写等更多高级知识挖掘功能

主要研究问题 ​

  1. 睡眠障碍和炎症如何具体影响阿尔茨海默病的发病机制？
  2. 是否存在有效的干预措施来改善睡眠质量，从而降低阿尔茨海默病的风险？
  3. 研究中提到的β-淀粉样蛋白负担增加与睡眠障碍之间的关系如何具体表现？
  4. 有哪些生物标志物可以用来评估睡眠障碍对阿尔茨海默病风险的影响？
  5. 在不同年龄段中，睡眠障碍对阿尔茨海默病的影响是否存在显著差异？

核心洞察 ​

研究背景和目的 ​

随着全球老龄化问题的加剧，老年人群中睡眠障碍的发生率逐渐上升。据研究，近一半的60岁以上成年人报告存在睡眠问题，这可能表现为失眠、睡眠质量或数量不佳，甚至遭遇失眠障碍。睡眠障碍不仅影响生活质量，还可能与认知能力下降相关联，进而增加阿尔茨海默病痴呆的风险。因此，本研究旨在探讨睡眠障碍与阿尔茨海默病之间的关系，特别关注炎症在这一过程中的作用。

主要方法和发现 ​

研究通过分析现有文献和临床数据，探讨了睡眠障碍如何影响阿尔茨海默病的发病机制。研究发现，睡眠障碍不仅是阿尔茨海默病的后果，还可能作为一种风险因素，促进β-淀粉样蛋白负担的增加。具体来说，睡眠障碍会导致全身性炎症的增加，而炎症被认为是阿尔茨海默病发病的早期事件。这一发现打破了传统观点，强调了睡眠障碍与阿尔茨海默病之间存在双向关系。

核心结论 ​

研究得出结论，睡眠障碍和炎症是可修改的风险因素，二者之间的相互作用可能在阿尔茨海默病的发展中起到重要作用。通过深入理解睡眠障碍与阿尔茨海默病之间的机制，未来有望确定针对阿尔茨海默病预防的干预目标。

研究意义和影响 ​

本研究的意义在于揭示了睡眠障碍与阿尔茨海默病之间的复杂关系，为临床干预提供了新思路。了解睡眠和炎症的相互作用有助于开发新的预防策略，可能通过改善睡眠质量和降低炎症反应来减缓阿尔茨海默病的进展。这不仅能提高老年人的生活质量，还有助于减轻社会医疗负担，对于公共卫生政策的制定具有重要的指导意义。

引用本文的文献 ​

  1. Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease. - Nicolaas I Bohnen;Michele T M Hu - Journal of Parkinson's disease (2019)
  2. Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database. - Masayo Ogawa;Kazushi Maruo;Daichi Sone;Hiroyuki Shimada;Keisuke Suzuki;Hiroshi Watanabe;Hiroshi Matsuda;Hidehiro Mizusawa - Alzheimer's & dementia (New York, N. Y.) (2019)
  3. Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression. - Carmen Andreescu;Olusola Ajilore;Howard J Aizenstein;Kimberly Albert;Meryl A Butters;Bennett A Landman;Helmet T Karim;Robert Krafty;Warren D Taylor - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (2019)
  4. Sleep and neuropsychiatric illness. - John W Winkelman;Luis de Lecea - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2020)
  5. Nocturnal Gamma-Hydroxybutyrate Reduces Cortisol-Awakening Response and Morning Kynurenine Pathway Metabolites in Healthy Volunteers. - D A Dornbierer;M Boxler;C D Voegel;B Stucky;A E Steuer;T M Binz;M R Baumgartner;D M Baur;B B Quednow;T Kraemer;E Seifritz;H P Landolt;O G Bosch - The international journal of neuropsychopharmacology (2019)
  6. Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases. - Vanessa Silva Gontijo;Flávia P Dias Viegas;Cindy Juliet Cristancho Ortiz;Matheus de Freitas Silva;Caio Miranda Damasio;Mayara Chagas Rosa;Thâmara Gaspar Campos;Dyecika Souza Couto;Kris Simone Tranches Dias;Claudio Viegas - Current neuropharmacology (2020)
  7. Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium. - Anders M Fjell;Øystein Sørensen;Inge K Amlien;David Bartrés-Faz;Didac Maciá Bros;Nikolaus Buchmann;Ilja Demuth;Christian A Drevon;Sandra Düzel;Klaus P Ebmeier;Ane-Victoria Idland;Tim C Kietzmann;Rogier Kievit;Simone Kühn;Ulman Lindenberger;Athanasia M Mowinckel;Lars Nyberg;Darren Price;Claire E Sexton;Cristina Solé-Padullés;Sara Pudas;Donatas Sederevicius;Sana Suri;Gerd Wagner;Leiv Otto Watne;René Westerhausen;Enikő Zsoldos;Kristine B Walhovd - Sleep (2020)
  8. The mediating role of low-grade inflammation on the prospective association between sleep and cognitive function in older men and women: 8-year follow-up from the English Longitudinal Study of Ageing. - Marta Jackowska;Dorina Cadar - Archives of gerontology and geriatrics (2020)
  9. Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. - A B Niculescu;H Le-Niculescu;K Roseberry;S Wang;J Hart;A Kaur;H Robertson;T Jones;A Strasburger;A Williams;S M Kurian;B Lamb;A Shekhar;D K Lahiri;A J Saykin - Molecular psychiatry (2020)
  10. Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis. - Wei Xu;Chen-Chen Tan;Juan-Juan Zou;Xi-Peng Cao;Lan Tan - Journal of neurology, neurosurgery, and psychiatry (2020)

... (241 更多 篇文献)

© 2025 MaltSci 麦伴科研 - 我们用人工智能技术重塑科研