A brief history of synthetic biology.

文献信息

DOI	10.1038/nrmicro3239
PMID	24686414
期刊	Nature reviews. Microbiology
影响因子	103.3
JCR 分区	Q1
发表年份	2014
被引次数	274
关键词	合成生物学, 微生物工程, 基因组学, 系统生物学, 生物技术
文献类型	Historical Article, Research Support, Non-U.S. Gov't, Review, Journal Article
ISSN	1740-1526
页码	381-90
期号	12(5)
作者	D Ewen Cameron, Caleb J Bashor, James J Collins

一句话小结

合成生物学作为一门新兴工程学科，旨在设计和控制微生物的行为，其发展历程受益于基因组学和系统生物学的革命，近年来在生物技术和医学领域展现出巨大的变革潜力。本文回顾了合成生物学的技术进展和文化演变，强调了关键突破及其未来面临的挑战。

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合成生物学 · 微生物工程 · 基因组学 · 系统生物学 · 生物技术

摘要

理性地设计微生物的能力是一个早已设想的目标，追溯可达五十多年前。随着1990年代基因组学革命和系统生物学的兴起，诞生了一门严谨的工程学科，旨在创造、控制和编程细胞行为。由此产生的领域称为合成生物学，在过去十年中经历了显著的增长，并有望在生物技术和医学领域引发变革。本文时间线文章描绘了合成生物学的技术和文化发展历程，重点关注关键突破和未来挑战。

英文摘要

The ability to rationally engineer microorganisms has been a long-envisioned goal dating back more than a half-century. With the genomics revolution and rise of systems biology in the 1990s came the development of a rigorous engineering discipline to create, control and programme cellular behaviour. The resulting field, known as synthetic biology, has undergone dramatic growth throughout the past decade and is poised to transform biotechnology and medicine. This Timeline article charts the technological and cultural lifetime of synthetic biology, with an emphasis on key breakthroughs and future challenges.

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主要研究问题

核心洞察

研究背景和目的
合成生物学的概念源于对微生物合理工程化的长久愿景，已有超过五十年的历史。随着1990年代基因组学革命和系统生物学的兴起，科学界开始发展出一门严谨的工程学科，旨在创造、控制和编程细胞行为。该研究旨在回顾合成生物学的发展历程，强调其中的关键突破和未来面临的挑战，探讨其对生物技术和医学领域的潜在变革。
主要方法和发现
本文采用时间轴的方式，系统梳理了合成生物学从起步到如今的技术和文化历程，重点关注了关键技术突破的时点和相关背景。这些突破包括基因组编辑技术的进步、代谢工程的发展，以及标准化生物部件的创建等。此外，文章还讨论了合成生物学在实际应用中的成功案例和面临的伦理、监管等挑战。
核心结论
合成生物学作为一个新兴领域，已经取得了显著进展，其技术的发展正在为生物技术和医学带来深远影响。未来，合成生物学不仅有望提高生物制造的效率，还可能在疾病治疗、环境保护等方面发挥重要作用。然而，该领域的发展也伴随着一系列挑战，包括技术的安全性、伦理问题以及政策法规的适应性等。
研究意义和影响
本研究不仅为合成生物学的历史发展提供了一个清晰的脉络，也为未来的研究方向和应用提供了重要的参考。随着技术的不断进步，合成生物学可能会在多个领域引发革命性变化，从药物开发到可再生能源的生产，均可能受益于这一领域的创新。同时，研究揭示的挑战也促使科学家和政策制定者更加重视伦理和安全问题，以确保合成生物学的可持续发展。

参考文献

The second wave of synthetic biology: from modules to systems. - Priscilla E M Purnick;Ron Weiss - Nature reviews. Molecular cell biology (2009)
Model-driven engineering of RNA devices to quantitatively program gene expression. - James M Carothers;Jonathan A Goler;Darmawi Juminaga;Jay D Keasling - Science (New York, N.Y.) (2011)
A synthetic multicellular system for programmed pattern formation. - Subhayu Basu;Yoram Gerchman;Cynthia H Collins;Frances H Arnold;Ron Weiss - Nature (2005)
A sensing array of radically coupled genetic 'biopixels'. - Arthur Prindle;Phillip Samayoa;Ivan Razinkov;Tal Danino;Lev S Tsimring;Jeff Hasty - Nature (2011)
Creation of a bacterial cell controlled by a chemically synthesized genome. - Daniel G Gibson;John I Glass;Carole Lartigue;Vladimir N Noskov;Ray-Yuan Chuang;Mikkel A Algire;Gwynedd A Benders;Michael G Montague;Li Ma;Monzia M Moodie;Chuck Merryman;Sanjay Vashee;Radha Krishnakumar;Nacyra Assad-Garcia;Cynthia Andrews-Pfannkoch;Evgeniya A Denisova;Lei Young;Zhi-Qing Qi;Thomas H Segall-Shapiro;Christopher H Calvey;Prashanth P Parmar;Clyde A Hutchison;Hamilton O Smith;J Craig Venter - Science (New York, N.Y.) (2010)
Protein molecules as computational elements in living cells. - D Bray - Nature (1995)
Engineered riboregulators enable post-transcriptional control of gene expression. - Farren J Isaacs;Daniel J Dwyer;Chunming Ding;Dmitri D Pervouchine;Charles R Cantor;James J Collins - Nature biotechnology (2004)
Synthetic biology moving into the clinic. - Warren C Ruder;Ting Lu;James J Collins - Science (New York, N.Y.) (2011)
Standard biological parts knowledgebase. - Michal Galdzicki;Cesar Rodriguez;Deepak Chandran;Herbert M Sauro;John H Gennari - PloS one (2011)
Higher-order cellular information processing with synthetic RNA devices. - Maung Nyan Win;Christina D Smolke - Science (New York, N.Y.) (2008)

引用本文的文献

Advances and computational tools towards predictable design in biological engineering. - Lorenzo Pasotti;Susanna Zucca - Computational and mathematical methods in medicine (2014)
Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules. - Christine Delbarre-Ladrat;Corinne Sinquin;Lou Lebellenger;Agata Zykwinska;Sylvia Colliec-Jouault - Frontiers in chemistry (2014)
Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. - Quin H Christensen;Ryan M Brecht;Dastagiri Dudekula;E Peter Greenberg;Rajesh Nagarajan - PloS one (2014)
Tunable protein degradation in bacteria. - D Ewen Cameron;James J Collins - Nature biotechnology (2014)
In vivo evolution of metabolic pathways: Assembling old parts to build novel and functional structures. - Alejandro Luque;Sarra C Sebai;Vincent Sauveplane;Odile Ramaen;Rudy Pandjaitan - Bioengineered (2014)
Synthetic Biology: A Bridge between Artificial and Natural Cells. - Yunfeng Ding;Fan Wu;Cheemeng Tan - Life (Basel, Switzerland) (2014)
Establishing Chlamydomonas reinhardtii as an industrial biotechnology host. - Mark A Scaife;Ginnie T D T Nguyen;Juan Rico;Devinn Lambert;Katherine E Helliwell;Alison G Smith - The Plant journal : for cell and molecular biology (2015)
Engineering Sugar Utilization and Microbial Tolerance toward Lignocellulose Conversion. - Lizbeth M Nieves;Larry A Panyon;Xuan Wang - Frontiers in bioengineering and biotechnology (2015)
Mammalian synthetic biology: emerging medical applications. - Zoltán Kis;Hugo Sant'Ana Pereira;Takayuki Homma;Ryan M Pedrigi;Rob Krams - Journal of the Royal Society, Interface (2015)
Cosmetics-triggered percutaneous remote control of transgene expression in mice. - Hui Wang;Haifeng Ye;Mingqi Xie;Marie Daoud El-Baba;Martin Fussenegger - Nucleic acids research (2015)

... (264 更多篇文献)

A brief history of synthetic biology. ​

文献信息 ​

一句话小结 ​

在麦伴科研 (maltsci.com) 搜索更多文献 ​

摘要 ​

英文摘要 ​

麦伴智能科研服务 ​

主要研究问题 ​

核心洞察 ​

参考文献 ​

引用本文的文献 ​