Curated Papers > Recent research on high-impact "CAR-T therapy" (IF≥30, last 5 years)

Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward.

Literature Information

DOI	10.3322/caac.21697
PMID	34546590
Journal	CA: a cancer journal for clinicians
Impact Factor	232.4
JCR Quartile	Q1
Publication Year	2021
Times Cited	79
Keywords	antibiotic resistance, antibiotics, bacterial infections, cancer
Literature Type	Journal Article, Review
ISSN	0007-9235
Pages	488-504
Issue	71(6)
Authors	Amila K Nanayakkara, Helen W Boucher, Vance G Fowler, Amanda Jezek, Kevin Outterson, David E Greenberg

TL;DR

This review addresses the critical issue of antibiotic resistance in cancer patients, particularly concerning ESKAPE pathogens, which poses significant health and financial challenges in this vulnerable population. The authors advocate for enhanced surveillance and preventive measures to combat antibiotic resistance, emphasizing the need for better data and strategies to improve care for cancer patients facing infections.

Search for more papers on MaltSci.com

antibiotic resistance · antibiotics · bacterial infections · cancer

Abstract

Infection is the second leading cause of death in patients with cancer. Loss of efficacy in antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing success of cancer therapy. In this review, the authors focus on recent updates on the impact of antibiotic resistance in the cancer setting, particularly on the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.). This review highlights the health and financial impact of antibiotic resistance in patients with cancer. Furthermore, the authors recommend measures to control the emergence of antibiotic resistance, highlighting the risk factors associated with cancer care. A lack of data in the etiology of infections, specifically in oncology patients in United States, is identified as a concern, and the authors advocate for a centralized and specialized surveillance system for patients with cancer to predict and prevent the emergence of antibiotic resistance. Finding better ways to predict, prevent, and treat antibiotic-resistant infections will have a major positive impact on the care of those with cancer.

MaltSci.com AI Research Service

Intelligent ReadingAnswer any question about the paper and explain complex charts and formulas

Locate StatementsFind traces of a specific claim within the paper

Add to KBasePerform data extraction, report drafting, and advanced knowledge mining

Primary Questions Addressed

1. What specific strategies can be implemented to mitigate the risk of antibiotic resistance in cancer patients undergoing treatment?
2. How do the ESKAPE pathogens specifically affect the prognosis of cancer patients with infections?
3. What role does patient education play in preventing antibiotic resistance among cancer patients?
4. Are there particular cancer treatments that are more susceptible to complications from antibiotic-resistant infections?
5. How can the healthcare system improve data collection on infections in oncology patients to better address antibiotic resistance?

Key Findings

Key Insights

1. Research Background and Objective

Antibiotic resistance poses a significant threat to patients with cancer, as infections are the second leading cause of death in this population. The review focuses on the implications of antibiotic resistance, specifically in relation to ESKAPE pathogens, which are notorious for their ability to evade antibiotic treatment. The primary objective is to update the understanding of how antibiotic resistance affects cancer care and to propose actionable measures to mitigate its impact.

2. Main Methods and Findings

The authors conducted a comprehensive review of recent literature concerning antibiotic resistance in oncology patients, focusing on the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. They assessed the health and financial burdens associated with infections caused by these resistant bacteria in cancer patients. Key findings indicate that the prevalence of antibiotic-resistant infections is rising, which complicates treatment regimens and leads to increased morbidity, mortality, and healthcare costs. The review also identifies a significant gap in data regarding the etiology of infections in cancer patients in the United States, highlighting the need for a more robust surveillance system to track and predict antibiotic resistance trends.

3. Core Conclusions

The authors conclude that the escalation of antibiotic resistance in cancer patients necessitates urgent attention and action. Effective management of antibiotic-resistant infections is critical for improving patient outcomes and reducing healthcare expenditures. They advocate for the establishment of a centralized surveillance system tailored to oncology patients, which would enable better tracking of infection trends and resistance patterns, ultimately leading to more informed clinical decision-making.

4. Research Significance and Impact

This review underscores the urgent need to address antibiotic resistance as a public health crisis, particularly in vulnerable populations such as cancer patients. The findings highlight the interconnectedness of antibiotic resistance and cancer care, suggesting that improvements in infection control practices, surveillance, and targeted treatment strategies could significantly enhance patient care. By advocating for specialized monitoring and tailored interventions, the research aims to foster a proactive approach in combating antibiotic resistance, thereby preserving the efficacy of cancer treatments and improving overall patient survival rates. The insights from this review could serve as a blueprint for future research and policy initiatives aimed at tackling antibiotic resistance in the oncology setting.

Literatures Citing This Work

1. REASSURED Multiplex Diagnostics: A Critical Review and Forecast. - Jonas A Otoo;Travis S Schlappi - Biosensors (2022)
2. Filamentous Thermosensitive Mutant Z: An Appealing Target for Emerging Pathogens and a Trek on Its Natural Inhibitors. - Manisha Gurnani;Abhishek Chauhan;Anuj Ranjan;Hardeep Singh Tuli;Mustfa F Alkhanani;Shafiul Haque;Kuldeep Dhama;Rup Lal;Tanu Jindal - Biology (2022)
3. Pseudomonas aeruginosa Infections in Cancer Patients. - Paulina Paprocka;Bonita Durnaś;Angelika Mańkowska;Grzegorz Król;Tomasz Wollny;Robert Bucki - Pathogens (Basel, Switzerland) (2022)
4. Bacteriological Spectrum and Antibiotic Susceptibility on Blood Culture in Newly Diagnosed Pediatric Patients With Acute Lymphoblastic Leukemia During the Induction Phase. - Usman Fawad - Cureus (2022)
5. Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics. - Carla C C R de Carvalho - Bioengineering (Basel, Switzerland) (2022)
6. Determination of Sulphonamides and Tetracycline Residues in Liver Tissues of Broiler Chicken Sold in Kinondoni and Ilala Municipalities, Dar es Salaam, Tanzania. - Winstone J Ulomi;Fauster X Mgaya;Zuhura Kimera;Mecky I Matee - Antibiotics (Basel, Switzerland) (2022)
7. Advancements in antimicrobial nanoscale materials and self-assembling systems. - Jack A Doolan;George T Williams;Kira L F Hilton;Rajas Chaudhari;John S Fossey;Benjamin T Goult;Jennifer R Hiscock - Chemical Society reviews (2022)
8. Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay. - Eddy E Alfonso;Zifang Deng;Daniel Boaretto;Becky L Hood;Stefan Vasile;Layton H Smith;Jeremy W Chambers;Prem Chapagain;Fenfei Leng - ACS pharmacology & translational science (2022)
9. Bidirectional Functional Effects of Staphylococcus on Carcinogenesis. - Yuannan Wei;Esha Sandhu;Xi Yang;Jie Yang;Yuanyuan Ren;Xingjie Gao - Microorganisms (2022)
10. Penicillin allergy delabeling: Opportunities for implementation and dissemination. - Upeka Samarakoon;John Accarino;Alysse G Wurcel;Jordon Jaggers;Allen Judd;Kimberly G Blumenthal - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2023)

... (69 more literatures)

---

© 2025 MaltSci - We reshape scientific research with AI technology