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Curated Papers > Recent high-impact studies on the "tumor microenvironment" (IF≥30, past 5 years)

Innate immune cells in the tumor microenvironment. ​

Literature Information ​

DOI10.1016/j.ccell.2021.05.016
PMID34129817
JournalCancer cell
Impact Factor44.5
JCR QuartileQ1
Publication Year2021
Times Cited73
Keywordstumor immune microenvironment, innate immune cells, immunotherapy
Literature TypeJournal Article
ISSN1535-6108
Pages725-729
Issue39(6)
AuthorsMing O Li, Natalie Wolf, David H Raulet, Leila Akkari, Mikael J Pittet, Paulo C Rodriguez, Rosandra N Kaplan, Ariel Munitz, Zemin Zhang, Sijin Cheng, Nina Bhardwaj

TL;DR ​

This research focuses on the tumor immune microenvironment (TIME), highlighting the complex interactions between adaptive and innate immune cells that can both promote and inhibit tumor growth. The study emphasizes recent advances in understanding the diversity and functionality of innate immune cells in the TIME, which is critical for improving responses to immunotherapies and identifying new therapeutic strategies.

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tumor immune microenvironment · innate immune cells · immunotherapy

Abstract ​

The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.

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Primary Questions Addressed ​

  1. How do different types of innate immune cells interact with adaptive immune cells in the tumor microenvironment?
  2. What specific mechanisms do innate immune cells use to promote or inhibit tumor growth in various cancer types?
  3. In what ways can the plasticity of innate immune cells in the tumor microenvironment influence the efficacy of immunotherapies?
  4. What are the latest findings regarding the role of innate immune cells in shaping the tumor microenvironment and its impact on cancer progression?
  5. How can targeting innate immune cell pathways enhance the effectiveness of existing cancer treatments?

Key Findings ​

Key Insights on "Innate Immune Cells in the Tumor Microenvironment"

  1. Research Background and Purpose: The tumor immune microenvironment (TIME) is recognized as a multifaceted ecosystem that encompasses both adaptive and innate immune cells. These cells exhibit diverse roles, contributing to either tumor promotion or suppression. Understanding the intricate dynamics of innate immune cells within the TIME is crucial for deciphering their influence on tumor behavior and patient responses to immunotherapies. The purpose of this research is to explore the complexity and variability of innate immune cells, their functional roles in cancer progression, and their potential implications for improving immunotherapeutic strategies.

  2. Main Methods and Findings: The authors engage in a comprehensive review of recent literature, synthesizing findings from various studies that investigate the biology of innate immune cells in relation to cancer. They discuss the plasticity of these cells, which allows them to adapt their functions based on the tumor microenvironment. Key findings indicate that different subsets of innate immune cells, such as macrophages, dendritic cells, and natural killer (NK) cells, exhibit heterogeneous behaviors in response to tumor signals. Some may enhance tumor growth by promoting inflammation and immune evasion, while others can exert anti-tumor effects by initiating immune responses. Additionally, the review highlights gaps in current knowledge regarding how these cells interact with one another and with tumor cells, as well as the implications of these interactions for therapeutic interventions.

  3. Core Conclusions: The study concludes that innate immune cells play a dualistic role in the TIME, being capable of both facilitating and inhibiting tumor development. Their plasticity and the complex signaling networks within the TIME are pivotal in determining the overall immune response to tumors. The authors emphasize that a deeper understanding of the functions and interactions of various innate immune cell types is essential for optimizing immunotherapy approaches, paving the way for more effective cancer treatments.

  4. Research Significance and Impact: This research holds significant implications for the field of cancer immunotherapy. By elucidating the roles of innate immune cells in the TIME, it provides insights that could inform the design of novel therapeutic strategies aimed at reprogramming these cells to enhance their anti-tumor properties. Furthermore, addressing the outstanding questions regarding the mechanisms of immune cell behavior in tumors can lead to breakthroughs in how we predict and enhance patient responses to existing immunotherapies. Ultimately, this work underscores the importance of harnessing the innate immune system as a powerful ally in the fight against cancer.

Literatures Citing This Work ​

  1. Functions of RNF Family in the Tumor Microenvironment and Drugs Prediction in Grade II/III Gliomas. - Jingwei Zhang;Zeyu Wang;Hao Zhang;Ziyu Dai;Xisong Liang;Shuwang Li;Xun Zhang;Fangkun Liu;Zhixiong Liu;Kui Yang;Quan Cheng - Frontiers in cell and developmental biology (2021)
  2. The Single-Cell Level Perspective of the Tumor Microenvironment and Its Remodeling by CAR-T Cells. - Sanxing Gao;Ryohichi Sugimura - Cancer treatment and research (2022)
  3. Neutrophils: New Critical Regulators of Glioma. - Guanyu Wang;Jinpeng Wang;Chaoshi Niu;Yan Zhao;Pengfei Wu - Frontiers in immunology (2022)
  4. Construction of a breast cancer prognosis model based on alternative splicing and immune infiltration. - Dongni Zhang;Wenping Lu;Zhili Zhuo;Heting Mei;Xiaoqing Wu;Yongjia Cui - Discover oncology (2022)
  5. Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy. - Sharon Grisaru-Tal;Marc E Rothenberg;Ariel Munitz - Nature immunology (2022)
  6. Regulation of dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment. - Xiaoxia Huang;Yao Wang;Wenhui Yang;Jing Dong;Lin Li - Frontiers in nutrition (2022)
  7. Immunotherapy of targeting MDSCs in tumor microenvironment. - Hongshu Sui;Shengyi Dongye;Xiaocui Liu;Xinghua Xu;Li Wang;Christopher Q Jin;Minhua Yao;Zhaoqing Gong;Daniel Jiang;Kexin Zhang;Yaling Liu;Hui Liu;Guomin Jiang;Yanping Su - Frontiers in immunology (2022)
  8. Characteristic of Molecular Subtypes in Lung Squamous Cell Carcinoma Based on Autophagy-Related Genes and Tumor Microenvironment Infiltration. - Jinjie Wang;Jiaqi Zhu;Yijie Tang;Anping Zhang;Tingting Zhou;Youlang Zhou;Jiahai Shi - Journal of oncology (2022)
  9. Osthole: An up-to-date review of its anticancer potential and mechanisms of action. - Shaojie Yang;Wanlin Dai;Jingnan Wang;Xiaolin Zhang;Yuting Zheng;Shiyuan Bi;Liwei Pang;Tengqi Ren;Ye Yang;Yang Sun;Zhuyuan Zheng;Shuodong Wu;Jing Kong - Frontiers in pharmacology (2022)
  10. Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy. - Yuze Wu;Ming Yi;Mengke Niu;Qi Mei;Kongming Wu - Molecular cancer (2022)

... (63 more literatures)

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