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Blueprint for cancer research: Critical gaps and opportunities.
Literature Information
| DOI | 10.3322/caac.21652 |
|---|---|
| PMID | 33326126 |
| Journal | CA: a cancer journal for clinicians |
| Impact Factor | 232.4 |
| JCR Quartile | Q1 |
| Publication Year | 2021 |
| Times Cited | 44 |
| Keywords | cancer modeling, cancer screening, cancer treatment, precision medicine |
| Literature Type | Journal Article, Research Support, Non-U.S. Gov't |
| ISSN | 0007-9235 |
| Pages | 107-139 |
| Issue | 71(2) |
| Authors | Lynne W Elmore, Susanna F Greer, Elvan C Daniels, Charles C Saxe, Michael H Melner, Ginger M Krawiec, William G Cance, William C Phelps |
TL;DR
This research highlights the transformative impact of advancements in cancer screening, therapies, and biological understanding on personalized cancer care, while emphasizing the need for improved coordination among researchers and caregivers to implement evidence-based programs effectively. By integrating insights from over 90 cancer experts, the authors identify current challenges and advocate for a diverse national research portfolio to enhance cancer treatment and support for all communities.
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cancer modeling · cancer screening · cancer treatment · precision medicine
Abstract
We are experiencing a revolution in cancer. Advances in screening, targeted and immune therapies, big data, computational methodologies, and significant new knowledge of cancer biology are transforming the ways in which we prevent, detect, diagnose, treat, and survive cancer. These advances are enabling durable progress in the goal to achieve personalized cancer care. Despite these gains, more work is needed to develop better tools and strategies to limit cancer as a major health concern. One persistent gap is the inconsistent coordination among researchers and caregivers to implement evidence-based programs that rely on a fuller understanding of the molecular, cellular, and systems biology mechanisms underpinning different types of cancer. Here, the authors integrate conversations with over 90 leading cancer experts to highlight current challenges, encourage a robust and diverse national research portfolio, and capture timely opportunities to advance evidence-based approaches for all patients with cancer and for all communities.
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Primary Questions Addressed
- What specific evidence-based programs are currently lacking in coordination among cancer researchers and caregivers?
- How can advances in big data and computational methodologies be better integrated into cancer research to address existing gaps?
- What role does understanding the molecular and cellular mechanisms of cancer play in developing personalized treatment strategies?
- In what ways can the integration of diverse perspectives from leading cancer experts enhance the effectiveness of cancer research initiatives?
- What are the most significant challenges faced by researchers in implementing innovative cancer therapies across different communities?
Key Findings
1. Research Background and Objectives
The field of cancer research is undergoing significant transformation due to advancements in various areas such as screening technologies, the development of targeted and immune therapies, and the utilization of big data and computational methods. The primary aim of this research is to identify critical gaps in cancer treatment and management, while also highlighting opportunities for improving personalized cancer care. The authors emphasize the necessity of a coordinated approach among researchers and healthcare providers to effectively implement evidence-based programs, ultimately striving to mitigate cancer's impact as a major health concern.
2. Major Methods and Findings
The authors conducted extensive discussions with over 90 leading cancer experts to gather insights on the current landscape of cancer research. Through these dialogues, they identified several persistent challenges, including the lack of consistent coordination among stakeholders and the need for a deeper understanding of the molecular and cellular mechanisms of different cancer types. The findings reveal that, while progress has been made, there remains an urgent need for better tools and strategies to address the complexities of cancer biology and to enhance the overall effectiveness of cancer prevention, detection, diagnosis, and treatment.
3. Core Conclusions
The research underscores the critical need for a robust and diverse national research portfolio that integrates various domains of cancer science. It highlights that achieving personalized cancer care requires more than just technological advancements; it necessitates a cohesive effort to align research with clinical practice. The authors conclude that fostering collaboration among researchers, clinicians, and patients is essential to implementing effective evidence-based strategies that can cater to the diverse needs of cancer patients across different communities.
4. Research Significance and Impact
The significance of this research lies in its identification of the gaps and opportunities within the current cancer research framework. By advocating for a more integrated and coordinated approach, the authors aim to catalyze efforts that will lead to more effective cancer management strategies. The insights provided can guide policymakers, researchers, and healthcare providers in developing comprehensive programs that not only enhance the understanding of cancer biology but also translate into improved patient outcomes. Ultimately, this research contributes to the ongoing dialogue on how to optimize cancer care, ensuring that advances in the field benefit all patients and communities equitably.
Literatures Citing This Work
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- Ferroptosis-Related lncRNA Signature Correlates with the Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity of Esophageal Squamous Cell Carcinoma. - Jiahao Zhu;Yutian Zhao;Gang Wu;Xiaojun Zhang;Qingqing Chen;Bo Yang;Xinwei Guo;Shengjun Ji;Ke Gu - Oxidative medicine and cellular longevity (2022)
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