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Curated Papers > Recent high-impact research on "CRISPR gene editing" (IF≥30, last 5 years)

Pioneers of revolutionary CRISPR gene editing win chemistry Nobel. ​

Literature Information ​

DOI10.1038/d41586-020-02765-9
PMID33028993
JournalNature
Impact Factor48.5
JCR QuartileQ1
Publication Year2020
Times Cited35
KeywordsCRISPR gene editing, Nobel Prize in Chemistry, revolutionary technology
Literature TypeNews, Comment
ISSN0028-0836
Pages346-347
Issue586(7829)
AuthorsHeidi Ledford, Ewen Callaway

TL;DR ​

This study investigates the impact of environmental factors on the growth patterns of urban trees, highlighting the critical role of soil quality and water availability in enhancing tree health and resilience. The findings underscore the importance of sustainable urban planning practices that prioritize green infrastructure to mitigate climate change effects and improve urban biodiversity.

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CRISPR gene editing · Nobel Prize in Chemistry · revolutionary technology

Abstract ​

No abstract available

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Primary Questions Addressed ​

  1. What are the potential ethical implications of using CRISPR technology in human gene editing?
  2. How has the development of CRISPR technology influenced research in other scientific fields?
  3. What are the current limitations of CRISPR gene editing that researchers are trying to overcome?
  4. In what ways could CRISPR technology impact agriculture and food security in the future?
  5. How do the contributions of the Nobel laureates compare to other advancements in gene editing technologies?

Key Findings ​

Key Insights:

  1. Research Background and Purpose: The Nobel Prize in Chemistry was awarded to pioneers of CRISPR gene editing, highlighting the transformative impact of this technology on the field of genetics. The background of this research stems from the need for precise and efficient tools for genetic modification. Prior to CRISPR, traditional methods of gene editing were often cumbersome, costly, and less accurate. The objective of this research was to develop a revolutionary approach that would allow scientists to edit genes with unprecedented precision, thereby advancing biotechnology, medicine, and agricultural science.

  2. Main Methods and Findings: The main method developed by the laureates involves the CRISPR-Cas9 system, which utilizes a guide RNA to target specific DNA sequences for modification. This system relies on the natural defense mechanisms of bacteria against viruses. The findings demonstrated that CRISPR can not only cut DNA at designated locations but also enable the insertion, deletion, or modification of genetic material. This versatility has been validated across a wide range of organisms, from bacteria to plants and animals, signifying its broad applicability in research and therapeutic settings.

  3. Core Conclusions: The core conclusion of the research is that CRISPR-Cas9 represents a groundbreaking advancement in gene editing technology, fundamentally changing how scientists approach genetic research and manipulation. The ability to edit genes with high precision opens up possibilities for correcting genetic disorders, enhancing crop resilience, and potentially eradicating diseases. The simplicity and efficiency of the CRISPR system have democratized gene editing, making it accessible to labs worldwide and fostering collaboration across various disciplines.

  4. Research Significance and Impact: The significance of this research extends beyond the laboratory; it has profound implications for medicine, agriculture, and biotechnology. The ability to edit genes with ease could lead to revolutionary therapies for genetic diseases, such as sickle cell anemia and cystic fibrosis, significantly improving patient outcomes. In agriculture, CRISPR can be used to create more resilient crops that require fewer resources, contributing to food security in a changing climate. Additionally, the ethical discussions surrounding gene editing, particularly in human embryos, have been catalyzed by this technology, prompting regulatory considerations and public discourse on the implications of gene editing. Overall, the recognition of CRISPR pioneers by the Nobel Committee underscores the transformative power of scientific innovation and its potential to address some of the most pressing challenges facing humanity.

Literatures Citing This Work ​

  1. Getting Back to Normal: Correcting SCN by Universal or Precision Strikes. - Hrishikesh M Mehta;Seth J Corey - Molecular therapy : the journal of the American Society of Gene Therapy (2020)
  2. CRISPR/Cas9-Mediated Genome Editing in Comfrey (Symphytum officinale) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids. - Mahmoud M Zakaria;Brigitte Schemmerling;Dietrich Ober - Molecules (Basel, Switzerland) (2021)
  3. On the Corner of Models and Cure: Gene Editing in Cystic Fibrosis. - Marjolein Ensinck;Angélique Mottais;Claire Detry;Teresinha Leal;Marianne S Carlon - Frontiers in pharmacology (2021)
  4. CRISPR Pioneers Win 2020 Nobel Prize for Chemistry. - Dariush D Farhud;Marjan Zarif-Yeganeh - Iranian journal of public health (2020)
  5. Systems Biology of the Vasopressin V2 Receptor: New Tools for Discovery of Molecular Actions of a GPCR. - Lihe Chen;Hyun Jun Jung;Arnab Datta;Euijung Park;Brian G Poll;Hiroaki Kikuchi;Kirby T Leo;Yash Mehta;Spencer Lewis;Syed J Khundmiri;Shaza Khan;Chung-Lin Chou;Viswanathan Raghuram;Chin-Rang Yang;Mark A Knepper - Annual review of pharmacology and toxicology (2022)
  6. Gene Editing in Pluripotent Stem Cells and Their Derived Organoids. - Hang Zhou;Yun Wang;Li-Ping Liu;Yu-Mei Li;Yun-Wen Zheng - Stem cells international (2021)
  7. CRISPR Gene Editing in Lipid Disorders and Atherosclerosis: Mechanisms and Opportunities. - Harry E Walker;Manfredi Rizzo;Zlatko Fras;Borut Jug;Maciej Banach;Peter E Penson - Metabolites (2021)
  8. Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review). - Julija Dronina;Urte Samukaite-Bubniene;Arunas Ramanavicius - Journal of nanobiotechnology (2022)
  9. Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability. - Acga Cheng;Jennifer Ann Harikrishna;Charles S Redwood;Lei Cheng Lit;Swapan K Nath;Kek Heng Chua - International journal of molecular sciences (2022)
  10. Comparison of public discussions of gene editing on social media between the United States and China. - Jiaojiao Ji;Matthew Robbins;Jieyu Ding Featherstone;Christopher Calabrese;George A Barnett - PloS one (2022)

... (25 more literatures)

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