Curated Papers > In recent years, high-impact research in "synthetic biology" (IF≥30, last 5 years) has emerged.

Mechano-bactericidal actions of nanostructured surfaces.

Literature Information

DOI	10.1038/s41579-020-0414-z
PMID	32807981
Journal	Nature reviews. Microbiology
Impact Factor	103.3
JCR Quartile	Q1
Publication Year	2021
Times Cited	125
Keywords	Antibiotic resistance, Nanostructured surfaces, Biofilm formation, Physico-mechanical interactions
Literature Type	Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
ISSN	1740-1526
Pages	8-22
Issue	19(1)
Authors	Denver P Linklater, Vladimir A Baulin, Saulius Juodkazis, Russell J Crawford, Paul Stoodley, Elena P Ivanova

TL;DR

This review highlights the escalating threat of antibiotic resistance due to bacterial biofilm formation on medical devices, which complicates treatment of infections. It discusses the potential of nanostructured surfaces to prevent bacterial colonization through physico-mechanical interactions, offering a promising strategy for developing next-generation biomaterials that can effectively reduce bacterial infections.

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Antibiotic resistance · Nanostructured surfaces · Biofilm formation · Physico-mechanical interactions

Abstract

Antibiotic resistance is a global human health threat, causing routine treatments of bacterial infections to become increasingly difficult. The problem is exacerbated by biofilm formation by bacterial pathogens on the surfaces of indwelling medical and dental devices that facilitate high levels of tolerance to antibiotics. The development of new antibacterial nanostructured surfaces shows excellent prospects for application in medicine as next-generation biomaterials. The physico-mechanical interactions between these nanostructured surfaces and bacteria lead to bacterial killing or prevention of bacterial attachment and subsequent biofilm formation, and thus are promising in circumventing bacterial infections. This Review explores the impact of surface roughness on the nanoscale in preventing bacterial colonization of synthetic materials and categorizes the different mechanisms by which various surface nanopatterns exert the necessary physico-mechanical forces on the bacterial cell membrane that will ultimately result in cell death.

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Primary Questions Addressed

1. What are the specific mechanisms by which surface roughness at the nanoscale affects bacterial cell membranes?
2. How do different types of nanostructured surfaces compare in their effectiveness against various bacterial strains?
3. What role does the material composition of nanostructured surfaces play in their mechano-bactericidal properties?
4. How can the findings about mechano-bactericidal actions be applied to improve the design of medical devices?
5. What are the potential long-term implications of using nanostructured surfaces in clinical settings regarding bacterial resistance?

Key Findings

Key Insights

1. Research Background and Objective: The increasing prevalence of antibiotic resistance poses a significant threat to global health, complicating the treatment of bacterial infections. Biofilm formation by bacterial pathogens on medical and dental devices further exacerbates this issue, as biofilms provide enhanced tolerance to antibiotics. The objective of this study is to explore the potential of nanostructured surfaces as innovative antibacterial solutions that can prevent bacterial colonization and biofilm formation, thus providing an alternative to traditional antibiotic treatments.

2. Main Methods and Findings: The review focuses on the physico-mechanical interactions between nanostructured surfaces and bacteria. It discusses how variations in surface roughness at the nanoscale can effectively deter bacterial attachment. The authors categorize different nanopatterns and their mechanisms of action, emphasizing how they generate specific physico-mechanical forces that affect the bacterial cell membrane. The findings indicate that certain nanopatterns can lead to bacterial cell death through mechanisms such as membrane disruption, which effectively reduces the chances of biofilm development on synthetic materials.

3. Core Conclusions: The study concludes that nanostructured surfaces represent a promising avenue for the development of next-generation biomaterials in medical applications. By leveraging the unique properties of nanoscale surface roughness, these materials can significantly reduce bacterial colonization and biofilm formation. The effectiveness of these surfaces relies on their ability to induce mechanical stress on bacterial cells, leading to cell death and thereby offering a viable alternative to conventional antibiotic therapies.

4. Research Significance and Impact: This research holds substantial significance in the context of combating antibiotic resistance, which is a pressing issue in healthcare. The insights gained from understanding the mechano-bactericidal actions of nanostructured surfaces could lead to the design of more effective medical devices and implants that minimize the risk of infections. The implications of this work extend beyond immediate medical applications, potentially influencing future research in material science and bioengineering aimed at developing innovative solutions for infection control in various settings. Ultimately, this approach could contribute to improving patient outcomes and reducing the burden of antibiotic-resistant infections on health systems globally.

References

1. The significance of infection related to orthopedic devices and issues of antibiotic resistance. - Davide Campoccia;Lucio Montanaro;Carla Renata Arciola - Biomaterials (2006)
2. The antibiotic resistance crisis: part 1: causes and threats. - C Lee Ventola - P & T : a peer-reviewed journal for formulary management (2015)
3. A review of the biomaterials technologies for infection-resistant surfaces. - Davide Campoccia;Lucio Montanaro;Carla Renata Arciola - Biomaterials (2013)
4. Recent developments in smart antibacterial surfaces to inhibit biofilm formation and bacterial infections. - Xi Li;Biao Wu;Hao Chen;Kaihui Nan;Yingying Jin;Lin Sun;Bailiang Wang - Journal of materials chemistry. B (2018)
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Literatures Citing This Work

1. Second Harmonic Generation from Phase-Engineered Metasurfaces of Nanoprisms. - Kanta Mochizuki;Mako Sugiura;Hirofumi Yogo;Stefan Lundgaard;Jingwen Hu;Soon Hock Ng;Yoshiaki Nishijima;Saulius Juodkazis;Atsushi Sugita - Micromachines (2020)
2. Nanomaterials arising amid antibiotic resistance. - Weiwei Gao;Liangfang Zhang - Nature reviews. Microbiology (2021)
3. Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae. - Pawel Kallas;Håvard J Haugen;Nikolaj Gadegaard;John Stormonth-Darling;Mats Hulander;Martin Andersson;Håkon Valen - Nanomaterials (Basel, Switzerland) (2020)
4. A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle. - Yikai Wang;Wangsiyuan Teng;Zengjie Zhang;Xingzhi Zhou;Yuxiao Ye;Peng Lin;An Liu;Yan Wu;Binghao Li;Chongda Zhang;Xianyan Yang;Weixu Li;Xiaohua Yu;Zhongru Gou;Zhaoming Ye - Bioactive materials (2021)
5. Cell Rupture and Morphogenesis Control of the Dimorphic Yeast Candida albicans by Nanostructured Surfaces. - Naga Venkatesh Kollu;Dennis R LaJeunesse - ACS omega (2021)
6. Topographical nanostructures for physical sterilization. - Yujie Cai;Wei Bing;Xiao Xu;Yuqi Zhang;Zhaowei Chen;Zhen Gu - Drug delivery and translational research (2021)
7. Diversity of experimental designs for the fabrication of antifungal surfaces for the built environment. - Arturo Aburto-Medina;Phuc Hoang Le;Shane MacLaughlin;Elena Ivanova - Applied microbiology and biotechnology (2021)
8. Engineering biomaterials to prevent post-operative infection and fibrosis. - Aditya Josyula;Kunal S Parikh;Ian Pitha;Laura M Ensign - Drug delivery and translational research (2021)
9. Silver nanoparticles from insect wing extract: Biosynthesis and evaluation for antioxidant and antimicrobial potential. - Parameshwar Jakinala;Nageshwar Lingampally;Bee Hameeda;R Z Sayyed;Yahya Khan M;Elsayed Ahmed Elsayed;Hesham El Enshasy - PloS one (2021)
10. Resistance and Adaptation of Bacteria to Non-Antibiotic Antibacterial Agents: Physical Stressors, Nanoparticles, and Bacteriophages. - Sada Raza;Kinga Matuła;Sylwia Karoń;Jan Paczesny - Antibiotics (Basel, Switzerland) (2021)

... (115 more literatures)

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