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Curated Papers > High-impact authoritative literature on "tumor microenvironment"

Tumor Microenvironment. ​

Literature Information ​

DOI10.3390/medicina56010015
PMID31906017
JournalMedicina (Kaunas, Lithuania)
Impact Factor2.4
JCR QuartileQ1
Publication Year2019
Times Cited745
Keywordscancer, cancer-microenvironment, tumor, tumor-growth, tumor-microenvironment
Literature TypeJournal Article, Review
ISSN1010-660X
Issue56(1)
AuthorsBorros Arneth

TL;DR ​

This review highlights the significant role of the tumor microenvironment in cancer development and progression, emphasizing the interactions between malignant cells and various nonmalignant cells such as adipocytes and fibroblasts. By identifying these components, the study suggests that targeting the tumor microenvironment could enhance cancer treatment and improve health outcomes.

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cancer · cancer-microenvironment · tumor · tumor-growth · tumor-microenvironment

Abstract ​

BACKGROUND AND OBJECTIVES The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in all the stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation.

AIM This study aims to explore the concept of the tumor microenvironment by conducting a critical review of previous studies on the topic. Materials and Methods: This review relies on evidence presented in previous studies related to the topic. The articles included in this review were obtained from different medical and health databases.

RESULTS AND DISCUSSION The tumor microenvironment has received significant attention in the cancer literature, with a particular focus on its role in tumor development and progression. Previous studies have identified various components of the tumor microenvironment that influence malignant behavior and progression. In addition to malignant cells, adipocytes, fibroblasts, tumor vasculature, lymphocytes, dendritic cells, and cancer-associated fibroblasts are present in the tumor microenvironment. Each of these cell types has unique immunological capabilities that determine whether the tumor will survive and affect neighboring cells.

CONCLUSION The tumor microenvironment harbors cancer stem cells and other molecules that contribute to tumor development and progression. Consequently, targeting and manipulating the cells and factors in the tumor microenvironment during cancer treatment can help control malignancies and achieve positive health outcomes.

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Primary Questions Addressed ​

  1. How do specific cell types within the tumor microenvironment interact to influence tumor progression?
  2. What are the implications of targeting the tumor microenvironment in developing new cancer therapies?
  3. How do the properties of the tumor microenvironment differ between various types of cancers?
  4. What role do immune cells in the tumor microenvironment play in shaping the response to cancer treatments?
  5. How can understanding the tumor microenvironment lead to advancements in personalized medicine for cancer patients?

Key Findings ​

Background and Objectives ​

The tumor microenvironment (TME) plays a crucial role in tumorigenesis, as it comprises various cell types that interact with tumor cells through circulatory and lymphatic systems. This review aims to critically analyze existing literature on the TME to enhance understanding of its components and their implications in cancer development and progression.

Main Methods/Materials/Experimental Design ​

The review systematically analyzed studies from medical databases such as PsycINFO, CINAHL, PubMed, and Web of Science. Key search terms included "tumor microenvironment," "cancer stem cells," and "tumorigenesis." The literature was limited to English articles published between 2008 and 2017. The review followed a structured approach to evaluate the quality and relevance of selected articles.

Mermaid diagram

Key Results and Findings ​

The review identified 30 significant studies that highlighted various components of the TME, including:

  • Cell Types: Tumor cells, immune cells (e.g., macrophages, lymphocytes), fibroblasts, and endothelial cells.
  • Interactions: Tumor cells influence the TME through paracrine signaling, affecting immune responses and promoting angiogenesis.
  • Functional Roles: Nonmalignant cells in the TME often facilitate tumor growth and metastasis by promoting inflammatory responses and providing structural support.

Main Conclusions/Significance/Innovation ​

The TME is complex and heterogeneous, significantly influencing cancer behavior and treatment responses. Understanding the TME's role in tumor biology is vital for developing targeted therapies that can manipulate these interactions to improve patient outcomes. The review underscores the potential for targeting TME components in cancer treatment, particularly cancer stem cells and the inflammatory milieu.

Research Limitations and Future Directions ​

  • Limitations: The review is limited by the availability of literature and the focus on studies published within a specific timeframe. The complexity of TME interactions may not be fully captured.
  • Future Directions: Further research is needed to elucidate the dynamic interactions within the TME, explore the role of microbiota in cancer, and develop novel therapeutic strategies targeting TME components to enhance treatment efficacy.
AspectDetails
TME ComponentsTumor cells, immune cells, fibroblasts, ECM
Functional RolesSupport tumor growth, modulate immune responses
Research GapsNeed for more studies on TME dynamics and microbiota roles
Therapeutic TargetsCancer stem cells, TME signaling pathways

In summary, the TME is a critical factor in cancer progression and therapy response, representing a promising avenue for future cancer research and treatment development.

References ​

  1. The role of the tumor microenvironment in regulating angiogenesis. - Randolph S Watnick - Cold Spring Harbor perspectives in medicine (2012)
  2. Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth. - Kazuyoshi Shiga;Masayasu Hara;Takaya Nagasaki;Takafumi Sato;Hiroki Takahashi;Hiromitsu Takeyama - Cancers (2015)
  3. Treatment of advanced renal cell carcinoma patients with cabozantinib, an oral multityrosine kinase inhibitor of MET, AXL and VEGF receptors. - Arpita Desai;Eric J Small - Future oncology (London, England) (2019)
  4. Leukocyte trafficking in tumor microenvironment. - Annalisa Del Prete;Tiziana Schioppa;Laura Tiberio;Helena Stabile;Silvano Sozzani - Current opinion in pharmacology (2017)
  5. Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response. - Shamir Cassim;Jacques Pouyssegur - International journal of molecular sciences (2019)
  6. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. - Matthew Kraman;Paul J Bambrough;James N Arnold;Edward W Roberts;Lukasz Magiera;James O Jones;Aarthi Gopinathan;David A Tuveson;Douglas T Fearon - Science (New York, N.Y.) (2010)
  7. Biological effects of cancer-secreted factors on human mesenchymal stem cells. - Paula Y P Lam - Stem cell research & therapy (2013)
  8. Sustained lower rates of breast cancer in the United States. - Kathleen A Cronin;Peter M Ravdin;Brenda K Edwards - Breast cancer research and treatment (2009)
  9. Crosstalk between T lymphocytes and dendritic cells. - Claire Hivroz;Karine Chemin;Marie Tourret;Armelle Bohineust - Critical reviews in immunology (2012)
  10. The cellular and molecular origin of tumor-associated macrophages. - Ruth A Franklin;Will Liao;Abira Sarkar;Myoungjoo V Kim;Michael R Bivona;Kang Liu;Eric G Pamer;Ming O Li - Science (New York, N.Y.) (2014)

Literatures Citing This Work ​

  1. Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer. - Jacek Baj;Izabela Korona-Głowniak;Alicja Forma;Amr Maani;Elżbieta Sitarz;Mansur Rahnama-Hezavah;Elżbieta Radzikowska;Piero Portincasa - Cells (2020)
  2. Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications. - Neel Rajan;Tilak Khanal;Matthew D Ringel - Endocrine (2020)
  3. Role of Stromal Cells in Determining Tumor and Cancer Stem Cell Behaviors and Therapeutic Response. - Stephan J Reshkin;Rosa Angela Cardone - Cancers (2020)
  4. CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. - Jan Korbecki;Klaudyna Kojder;Donata Simińska;Romuald Bohatyrewicz;Izabela Gutowska;Dariusz Chlubek;Irena Baranowska-Bosiacka - International journal of molecular sciences (2020)
  5. Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-ras Transgenic Mice. - Shan-Ming Chen;Li-Jin Hsu;Hsiang-Lin Lee;Ching-Pin Lin;Szu-Wei Huang;Caucasus Jun-Lin Lai;Chia-Wei Lin;Wan-Ting Chen;Yu-Jen Chen;Yu-Chien Lin;Chi-Chieh Yang;Ming-Shiou Jan - Cancers (2020)
  6. The Tumor Microenvironment-A Metabolic Obstacle to NK Cells' Activity. - Joanna Domagala;Mieszko Lachota;Marta Klopotowska;Agnieszka Graczyk-Jarzynka;Antoni Domagala;Andriy Zhylko;Karolina Soroczynska;Magdalena Winiarska - Cancers (2020)
  7. A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults. - Chunkai Wen;Hongxue Wang;Han Wang;Hao Mo;Wuning Zhong;Jing Tang;Yongkui Lu;Wenxian Zhou;Aihua Tan;Yan Liu;Weimin Xie - Aging (2020)
  8. Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1. - Erica Buoso;Mirco Masi;Marco Racchi;Emanuela Corsini - International journal of molecular sciences (2020)
  9. Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy. - Changhua Mu;David E Korenchan;Sinan Wang;David M Wilson;Robert R Flavell - Molecular imaging and biology (2021)
  10. Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy. - Wen-Jun Zhang - Purinergic signalling (2021)

... (735 more literatures)

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