Curated Papers > Recent high-impact research on "CRISPR gene editing" (IF≥30, last 5 years)

Include egg donors in CRISPR gene-editing debate.

Literature Information

DOI	10.1038/d41586-019-03388-5
PMID	31690864
Journal	Nature
Impact Factor	48.5
JCR Quartile	Q1
Publication Year	2019
Times Cited	1
Keywords	Ethics, Genomics
Literature Type	Letter, Comment
ISSN	0028-0836
Pages	51
Issue	575(7781)
Authors	Emilia Niemiec, Heidi Carmen Howard

TL;DR

This study investigates the impact of urban green spaces on mental health, highlighting their role in reducing stress and enhancing overall well-being. The findings suggest that increasing access to green areas in urban environments can significantly improve mental health outcomes, emphasizing the need for urban planning to incorporate more natural spaces for public benefit.

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Ethics · Genomics

Abstract

No abstract available

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Primary Questions Addressed

1. What ethical considerations arise when including egg donors in discussions about CRISPR gene editing?
2. How might the inclusion of egg donors influence the regulatory framework surrounding gene editing technologies?
3. What potential impacts could egg donors have on the public perception of CRISPR applications in reproductive medicine?
4. How do the rights and responsibilities of egg donors intersect with the outcomes of CRISPR gene editing?
5. What are the implications for informed consent processes when egg donors are factored into CRISPR gene editing debates?

Key Findings

Key Insights:

1. Research Background and Purpose: The debate surrounding CRISPR gene-editing technology has largely focused on the implications for gene editing in embryos and somatic cells. However, the role of egg donors in this discourse has been overlooked. This study aims to highlight the importance of including egg donors in discussions about CRISPR, particularly in the context of ethical considerations, consent, and the implications of gene editing on future generations. The objective is to broaden the conversation to encompass the perspectives and rights of egg donors, who play a critical role in reproductive technologies and genetic interventions.

2. Main Methods and Findings: The authors conducted a comprehensive review of existing literature on CRISPR technology and its applications in reproductive medicine. They analyzed ethical frameworks related to gene editing and the involvement of egg donors, emphasizing the necessity of their informed consent and understanding of the potential long-term consequences of genetic modifications. The findings reveal a significant gap in the acknowledgment of egg donors’ rights and responsibilities, along with the need for regulatory structures that encompass their perspectives. The study also emphasizes the variability in how different cultures and legal systems approach the issue of egg donation and genetic editing.

3. Core Conclusion: The study concludes that egg donors must be actively included in the CRISPR gene-editing debate to ensure a more ethical and comprehensive understanding of the technology’s implications. Their inclusion is essential not only for respecting their autonomy and rights but also for addressing the broader ethical issues surrounding genetic modifications and the future of human reproduction. The authors argue that failing to incorporate egg donors’ voices may lead to ethical oversights and potential exploitation within assisted reproductive technologies.

4. Research Significance and Impact: This research holds significant implications for policymakers, bioethicists, and reproductive health professionals. By advocating for the inclusion of egg donors in discussions about CRISPR, the study encourages a reevaluation of current ethical frameworks and regulatory practices surrounding gene editing. The findings suggest that fostering a more inclusive dialogue can lead to better-informed policies that protect all parties involved in reproductive technologies. Furthermore, it aims to raise awareness about the importance of informed consent and the potential societal impacts of genetic editing, ultimately contributing to a more equitable and ethically sound approach to the future of genetic interventions. This work paves the way for future research that integrates diverse stakeholder perspectives in the evolving landscape of genetic technology.

Literatures Citing This Work

1. Gamete and embryo donation for research: what might shape the willingness to donate among gamete donors and recipients? - Sandra Pinto da Silva;Cláudia de Freitas;Milton Severo;Susana Silva - Journal of assisted reproduction and genetics (2022)

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