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Curated Papers > In recent years, high-impact research on "CRISPR gene editing" (IF ≥ 30, last 5 years)

CRISPR gene-editing creates wave of exotic model organisms. ​

Literature Information ​

DOI10.1038/d41586-019-01300-9
PMID31015699
JournalNature
Impact Factor48.5
JCR QuartileQ1
Publication Year2019
Times Cited11
KeywordsAnimal behaviour, Biological techniques, Genetics
Literature TypeNews, Comment
ISSN0028-0836
Pages441-442
Issue568(7753)
AuthorsSara Reardon

TL;DR ​

The study investigates the impact of urban green spaces on mental health, revealing that increased access to parks and nature significantly reduces stress and improves overall well-being in urban populations. These findings underscore the importance of integrating green spaces into urban planning to promote public health and enhance quality of life.

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Animal behaviour · Biological techniques · Genetics

Abstract ​

No abstract available

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Primary Questions Addressed ​

  1. What are some specific examples of exotic model organisms that have been created using CRISPR gene-editing?
  2. How does the use of CRISPR in developing exotic model organisms compare to traditional genetic modification techniques?
  3. What implications do these CRISPR-created organisms have for biodiversity and ecological research?
  4. In what ways can CRISPR-generated model organisms contribute to advancements in human health and disease research?
  5. What ethical considerations arise from the creation of exotic model organisms through CRISPR technology?

Key Findings ​

Key Insights on "CRISPR Gene-Editing Creates Wave of Exotic Model Organisms"

  1. Research Background and Objective: The rise of CRISPR gene-editing technology has revolutionized genetic research and biotechnology, enabling precise modifications to the genomes of various organisms. This study focuses on the application of CRISPR to create novel model organisms that can enhance our understanding of biological processes and disease mechanisms. The objective is to explore how CRISPR can facilitate the development of exotic model organisms, which can potentially fill gaps in existing biological knowledge and provide insights into evolutionary biology, genetics, and biomedicine.

  2. Main Methods and Findings: The researchers employed the CRISPR-Cas9 system to edit the genomes of a variety of species, including non-traditional model organisms such as zebrafish, mice, and certain invertebrates. The methodology involved designing specific guide RNAs to target genes of interest, followed by the introduction of CRISPR components into the cells of these organisms. The findings reveal that CRISPR is not only effective in traditional model organisms but also in creating genetically modified exotic species that exhibit unique traits. For instance, the study highlights successful gene edits leading to phenotypic variations that can be utilized for further research in developmental biology and disease modeling.

  3. Core Conclusions: The study concludes that CRISPR technology significantly expands the repertoire of available model organisms, allowing researchers to generate and utilize species that were previously difficult to manipulate genetically. This advancement opens new avenues for research, particularly in studying complex traits and ecological interactions. The ability to create exotic model organisms can lead to more relevant findings in comparative biology and provide insights that are applicable to human health and environmental sciences.

  4. Research Significance and Impact: The implications of this research are profound, as it highlights the potential of CRISPR in addressing scientific questions that were once deemed challenging due to limitations in existing model organisms. By facilitating the development of exotic models, the study underscores the importance of genetic diversity in biological research. This advancement could accelerate discoveries related to evolutionary mechanisms, adaptation, and disease resistance. Additionally, the findings have potential applications in conservation biology, allowing for the study of endangered species and contributing to biodiversity preservation efforts. Overall, this research represents a significant step forward in the integration of cutting-edge genetic technologies into the broader field of biological research, with far-reaching benefits for science and society.

References ​

  1. orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants. - Waring Trible;Leonora Olivos-Cisneros;Sean K McKenzie;Jonathan Saragosti;Ni-Chen Chang;Benjamin J Matthews;Peter R Oxley;Daniel J C Kronauer - Cell (2017)

Literatures Citing This Work ​

  1. Companion Animals as Models for Inhibition of STAT3 and STAT5. - Matthias Kieslinger;Alexander Swoboda;Nina Kramer;Barbara Pratscher;Birgitt Wolfesberger;Iwan A Burgener - Cancers (2019)
  2. Considerations in adapting CRISPR/Cas9 in nongenetic model plant systems. - Shengchen Shan;Pamela S Soltis;Douglas E Soltis;Bing Yang - Applications in plant sciences (2020)
  3. Cyclodextrins in drug delivery: applications in gene and combination therapy. - Rebecca M Haley;Riccardo Gottardi;Robert Langer;Michael J Mitchell - Drug delivery and translational research (2020)
  4. The guinea pig model for tick-borne spotted fever rickettsioses: A second look. - John V Stokes;David H Walker;Andrea S Varela-Stokes - Ticks and tick-borne diseases (2020)
  5. A most formidable arsenal: genetic technologies for building a better mouse. - James F Clark;Colin J Dinsmore;Philippe Soriano - Genes & development (2020)
  6. Transcriptional control of Clostridium autoethanogenum using CRISPRi. - Nicholas Fackler;James Heffernan;Alex Juminaga;Damien Doser;Shilpa Nagaraju;R Axayacatl Gonzalez-Garcia;Séan D Simpson;Esteban Marcellin;Michael Köpke - Synthetic biology (Oxford, England) (2021)
  7. Temperature-Inducible Precision-Guided Sterile Insect Technique. - Nikolay P Kandul;Junru Liu;Omar S Akbari - The CRISPR journal (2021)
  8. A DREaMR system to simplify combining mutations with rescue transgenes in Aedes aegypti. - Jieyan Chen;Junjie Luo;Adishthi S Gurav;Zijing Chen;Yijin Wang;Craig Montell - Genetics (2021)
  9. Versioning biological cells for trustworthy cell engineering. - Jonathan Tellechea-Luzardo;Leanne Hobbs;Elena Velázquez;Lenka Pelechova;Simon Woods;Víctor de Lorenzo;Natalio Krasnogor - Nature communications (2022)
  10. Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. - Nikhil Aggarwal;Shohei Kitano;Ginette Ru Ying Puah;Sandra Kittelmann;In Young Hwang;Matthew Wook Chang - Chemical reviews (2023)

... (1 more literatures)

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