Appearance
Tumor microenvironment: Sanctuary of the devil.
Literature Information
| DOI | 10.1016/j.canlet.2015.07.039 |
|---|---|
| PMID | 26276713 |
| Journal | Cancer letters |
| Impact Factor | 10.1 |
| JCR Quartile | Q1 |
| Publication Year | 2015 |
| Times Cited | 451 |
| Keywords | Combination therapy, Drug resistance, Tumor microenvironment |
| Literature Type | Journal Article, Research Support, Non-U.S. Gov't, Review |
| ISSN | 0304-3835 |
| Pages | 7-13 |
| Issue | 368(1) |
| Authors | Lanlan Hui, Ye Chen |
TL;DR
This paper reviews the interactions between tumor cells and their microenvironment, highlighting how these dynamics can inform new therapeutic strategies alongside traditional treatments. By providing insights into the pathophysiology of the tumor microenvironment, the authors emphasize its potential for guiding the development of effective combinational therapies for cancer eradication.
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Combination therapy · Drug resistance · Tumor microenvironment
Abstract
Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence indicates that targeting the tumor microenvironment could complement traditional treatment and improve therapeutic outcomes for these malignancies. In this paper, we review new insights into the tumor microenvironment, and summarize selected examples of the cross-talk between tumor cells and their microenvironment, which have enhanced our understanding of pathophysiology of the microenvironment. We believe that this rapidly moving field promises many more to come, and they will guide the rational design of combinational therapies for success in cancer eradication.
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Primary Questions Addressed
- How do specific components of the tumor microenvironment contribute to cancer cell resistance against therapies?
- What are the latest strategies for targeting the tumor microenvironment in combination with immunotherapy?
- How does the tumor microenvironment differ between various cancer types, and what implications does this have for treatment?
- In what ways can the study of tumor microenvironment inform the development of personalized medicine approaches for cancer patients?
- What role do immune cells play in the tumor microenvironment, and how can they be manipulated to enhance therapeutic efficacy?
Key Findings
Key Insights
Research Background and Purpose: The interaction between tumor cells and their surrounding microenvironment is a critical area of study in cancer research. The tumor microenvironment (TME) is not merely a passive backdrop but plays an active role in tumor progression, metastasis, and treatment resistance. This paper aims to explore the complexities of the TME and highlight the significance of targeting this environment as a complementary strategy to enhance the efficacy of traditional cancer therapies.
Main Methods and Findings: The authors conducted a comprehensive review of recent studies focusing on the dynamic interactions between tumor cells and various components of the TME, including stromal cells, immune cells, and extracellular matrix. They identified several key mechanisms of cross-talk, such as the secretion of growth factors and cytokines, which facilitate tumor growth and immune evasion. The paper summarizes various examples illustrating how these interactions contribute to tumor biology and influence therapeutic responses, thereby revealing potential targets for intervention.
Core Conclusions: The findings underscore that the tumor microenvironment is a "sanctuary" that supports tumor survival and growth, making it a critical target for cancer treatment. The paper concludes that understanding the TME's role in tumor behavior can lead to the rational design of combinational therapies that integrate traditional treatments with strategies aimed at modifying the microenvironment. Such approaches could potentially overcome the limitations of current therapies and lead to improved patient outcomes.
Research Significance and Impact: The insights provided in this paper are significant as they pave the way for innovative therapeutic strategies in oncology. By emphasizing the importance of the TME, the research encourages further investigation into how modifying the microenvironment can enhance the effectiveness of existing cancer treatments. This shift in focus from solely targeting tumor cells to also considering the TME could revolutionize cancer therapy, leading to more effective and personalized treatment options. The findings also highlight the need for interdisciplinary approaches that combine molecular biology, immunology, and pharmacology to tackle the complex challenges posed by cancer. As this field evolves, it holds the promise of significantly improving the prognosis for cancer patients by enabling more effective eradication of tumors through targeted therapies that disrupt the supportive roles of the tumor microenvironment.
Literatures Citing This Work
- Exosomes: small vesicles with big roles in hepatocellular carcinoma. - Zhitong Wu;Qinghai Zeng;Ke Cao;Yifan Sun - Oncotarget (2016)
- Interaction of MSC with tumor cells. - Catharina Melzer;Yuanyuan Yang;Ralf Hass - Cell communication and signaling : CCS (2016)
- Combination treatment including targeted therapy for advanced hepatocellular carcinoma. - Jianzhen Lin;Liangcai Wu;Xue Bai;Yuan Xie;Anqiang Wang;Haohai Zhang;Xiaobo Yang;Xueshuai Wan;Xin Lu;Xinting Sang;Haitao Zhao - Oncotarget (2016)
- Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. - Catharina Melzer;Juliane von der Ohe;Hendrik Lehnert;Hendrik Ungefroren;Ralf Hass - Molecular cancer (2017)
- E6/E7-P53-POU2F1-CTHRC1 axis promotes cervical cancer metastasis and activates Wnt/PCP pathway. - Rong Zhang;Huan Lu;Yuan-Yuan Lyu;Xiao-Mei Yang;Lin-Yan Zhu;Guang-Dong Yang;Peng-Cheng Jiang;Yuan Re;Wei-Wei Song;Jin-Hao Wang;Can-Can Zhang;Fei Gu;Tian-Jiao Luo;Zhi-Yong Wu;Cong-Jian Xu - Scientific reports (2017)
- Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness. - Simone Brivio;Massimiliano Cadamuro;Mario Strazzabosco;Luca Fabris - World journal of hepatology (2017)
- Reciprocal Interactions of Leukemic Cells with Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stem Cell Compartments in Response to Curcumin and Daunorubicin - Saeed Mohammadi;Mohsen Nikbakht;Seyed Mehdi Sajjadi;Fariba Rad;Bahram Chahardouli;Javid Sabour Takanlu;Shahrbano Rostami;Kamran Alimoghaddam;Ardeshir Ghavamzadeh;Seyed H Ghaffari - Asian Pacific journal of cancer prevention : APJCP (2017)
- Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism. - Balaraman Kalyanaraman - Redox biology (2017)
- Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. - Xiang Zheng;Kati Turkowski;Javier Mora;Bernhard Brüne;Werner Seeger;Andreas Weigert;Rajkumar Savai - Oncotarget (2017)
- Human Metaplastic Breast Carcinoma and Decorin. - Pia Boström;Annele Sainio;Natalja Eigėlienė;Anne Jokilammi;Klaus Elenius;Ilkka Koskivuo;Hannu Järveläinen - Cancer microenvironment : official journal of the International Cancer Microenvironment Society (2017)
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