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Plant synthetic biology.
Literature Information
| DOI | 10.1016/j.tplants.2015.02.004 |
|---|---|
| PMID | 25825364 |
| Journal | Trends in plant science |
| Impact Factor | 20.8 |
| JCR Quartile | Q1 |
| Publication Year | 2015 |
| Times Cited | 78 |
| Keywords | design cycle, enabling tools, engineering principles, pioneering applications, plant synthetic biology |
| Literature Type | Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review |
| ISSN | 1360-1385 |
| Pages | 309-317 |
| Issue | 20(5) |
| Authors | Wusheng Liu, C Neal Stewart |
TL;DR
This review highlights the role of plant synthetic biology in enhancing traditional agriculture and enabling novel bioproduction by integrating engineering principles with plant biology. It discusses design cycles, key engineering components, and computational tools, showcasing pioneering examples such as synthetic sensors and metabolic pathways, while speculating on the future impact of this field.
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design cycle · enabling tools · engineering principles · pioneering applications · plant synthetic biology
Abstract
Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants.
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Primary Questions Addressed
- How can plant synthetic biology contribute to sustainable agriculture practices?
- What are the ethical considerations surrounding the use of synthetic biology in crop modification?
- In what ways can synthetic biology enhance the nutritional content of staple crops?
- What challenges do researchers face when designing synthetic genomes for plants?
- How might computational tools evolve to better support the engineering of plant synthetic biology applications?
Key Findings
Key Insights
Research Background and Purpose: Plant synthetic biology is an interdisciplinary field that integrates engineering principles with plant biology, aiming to innovate the design and production of novel biological devices. As global challenges such as climate change, food security, and resource scarcity intensify, there is an urgent need for advanced agricultural practices and bioproduction methods. This research aims to explore how synthetic biology can not only enhance traditional crop improvement but also facilitate the development of new bioproducts through engineered plant systems.
Main Methods and Findings: The review discusses various design cycles and key engineering principles that underpin synthetic biology in plants. These include the use of standardized genetic parts, modular design approaches, and computational tools for modeling and simulation. The authors present pioneering examples that demonstrate the practical applications of synthetic biology in modifying plants for specific functionalities. Notable applications include the creation of synthetic sensors that can detect environmental changes, the engineering of synthetic metabolic pathways for enhanced production of valuable compounds, and the development of synthetic genomes that allow for more precise genetic modifications. These examples showcase the versatility and potential of synthetic biology in addressing specific agricultural and biotechnological needs.
Core Conclusions: The findings highlight that plant synthetic biology holds significant promise for revolutionizing agriculture and bioproduction. By leveraging engineering approaches, researchers can create plants with enhanced traits and functionalities that are tailored to meet specific demands. The successful implementation of synthetic biology techniques can lead to more resilient crops, improved yield, and the sustainable production of biochemicals. Furthermore, the ability to design and modify plant systems at a genetic level opens new avenues for research and application in various fields, including environmental sustainability and biofuel production.
Research Significance and Impact: The implications of this research extend beyond just agricultural enhancement. The integration of synthetic biology into plant science could lead to transformative changes in how crops are developed and utilized, potentially addressing critical issues such as food security and environmental degradation. By fostering innovation in plant engineering, this field can contribute to sustainable practices and the efficient use of natural resources. Moreover, the advancements in computational tools and genetic engineering techniques will likely accelerate the pace of research, paving the way for groundbreaking discoveries and applications in both academia and industry. Ultimately, plant synthetic biology could play a pivotal role in shaping the future of agriculture and biotechnology, enhancing both productivity and sustainability.
Literatures Citing This Work
- Synthetic biology for pharmaceutical drug discovery. - Jean-Yves Trosset;Pablo Carbonell - Drug design, development and therapy (2015)
- Biosynthesis of Essential Polyunsaturated Fatty Acids in Wheat Triggered by Expression of Artificial Gene. - Daniel Mihálik;Lenka Klčová;Katarína Ondreičková;Martina Hudcovicová;Marcela Gubišová;Tatiana Klempová;Milan Čertík;János Pauk;Ján Kraic - International journal of molecular sciences (2015)
- A modular toolbox for gRNA-Cas9 genome engineering in plants based on the GoldenBraid standard. - Marta Vazquez-Vilar;Joan Miquel Bernabé-Orts;Asun Fernandez-Del-Carmen;Pello Ziarsolo;Jose Blanca;Antonio Granell;Diego Orzaez - Plant methods (2016)
- Innovative farmers and regulatory gatekeepers: Genetically modified crops regulation and adoption in developing countries. - Woldeyesus Sinebo;Karim Maredia - GM crops & food (2016)
- Plant synthetic biology for molecular engineering of signalling and development. - Jennifer L Nemhauser;Keiko U Torii - Nature plants (2016)
- Advancing Crop Transformation in the Era of Genome Editing. - Fredy Altpeter;Nathan M Springer;Laura E Bartley;Ann E Blechl;Thomas P Brutnell;Vitaly Citovsky;Liza J Conrad;Stanton B Gelvin;David P Jackson;Albert P Kausch;Peggy G Lemaux;June I Medford;Martha L Orozco-Cárdenas;David M Tricoli;Joyce Van Eck;Daniel F Voytas;Virginia Walbot;Kan Wang;Zhanyuan J Zhang;C Neal Stewart - The Plant cell (2016)
- Mass spectrometry-guided refinement of chemical energy buffers. - T-R Chen;P L Urban - Proceedings. Mathematical, physical, and engineering sciences (2016)
- A Tightly Regulated Genetic Selection System with Signaling-Active Alleles of Phytochrome B. - Wei Hu;J Clark Lagarias - Plant physiology (2017)
- GB3.0: a platform for plant bio-design that connects functional DNA elements with associated biological data. - Marta Vazquez-Vilar;Alfredo Quijano-Rubio;Asun Fernandez-Del-Carmen;Alejandro Sarrion-Perdigones;Rocio Ochoa-Fernandez;Peio Ziarsolo;José Blanca;Antonio Granell;Diego Orzaez - Nucleic acids research (2017)
- MarpoDB: An Open Registry for Marchantia Polymorpha Genetic Parts. - Mihails Delmans;Bernardo Pollak;Jim Haseloff - Plant & cell physiology (2017)
... (68 more literatures)
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